ArticlePloS one2015
The Relationship between Native American Ancestry, Body Mass Index and Diabetes Risk among Mexican-Americans.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The effect of Indigenous American genomic ancestry on type 2 diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study.The Lancet. Public health · 2026Article
- Health Disparities Among Hispanic Patients With Type 2 Diabetes in the United States: An Educational Workshop.MedEdPORTAL : the journal of teaching and learning resources · 2026Article
- Admixture mapping identifies complex trait associations with local ancestry in themedRxiv : the preprint server for health sciences · 2025Article
- Molecular Ancestry Across Allelic Variants ofBiomedicines · 2025Article
- Associations between Life's Essential 8 scores and systemic immune-inflammation index among American-adult populations without cardiovascular disease.Frontiers in medicine · 2025Article
- National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990-2021, and forecasts up to 2050.Lancet (London, England) · 2024Article
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Article
- Inbreeding, Native American ancestry and child mortality: linking human selection and paediatric medicine.Human molecular genetics · 2022Article
- Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image archive.Frontiers in aging neuroscience · 2022Article
- Mortality attributable to sugar sweetened beverages consumption in Mexico: an update.International journal of obesity (2005) · 2020Article
- Association between APOE polymorphisms and lipid profile in Mexican Amerindian population.Molecular genetics & genomic medicine · 2019Article
- A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.Genetics · 2018Article
- Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile.PLoS genetics · 2017Article
- The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities.Frontiers in public health · 2017Review
- Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer's Disease Development in Mexico City Young Females.Journal of Alzheimer's disease : JAD · 2017Review
- Variability in Cancer Risk and Outcomes Within US Latinos by National Origin and Genetic Ancestry.Current epidemiology reports · 2016Review
- Tobacco Use, Insulin Resistance, and Risk of Type 2 Diabetes: Results from the Multi-Ethnic Study of Atherosclerosis.PloS one · 2016Article
- MS in self-identified Hispanic/Latino individuals living in the US.Multiple sclerosis journal - experimental, translational and clinicalReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Higher body mass index (BMI) is a well-established risk factor for type 2 diabetes, and rates of obesity and type 2 diabetes are substantially higher among Mexican-Americans relative to non-Hispanic European Americans. Mexican-Americans are genetically diverse, with a highly variable distribution of Native American, European, and African ancestries. Here, we evaluate the role of Native American ancestry on BMI and diabetes risk in a well-defined Mexican-American population. Participants were randomly selected among individuals residing in the Houston area who are enrolled in the Mexican-American Cohort study. Using a custom Illumina GoldenGate Panel, we genotyped DNA from 4,662 cohort participants for 87 Ancestry-Informative Markers. On average, the participants were of 50.2% Native American ancestry, 42.7% European ancestry and 7.1% African ancestry. Using multivariate linear regression, we found BMI and Native American ancestry were inversely correlated; individuals with <20% Native American ancestry were 2.5 times more likely to be severely obese compared to those with >80% Native American ancestry. Furthermore, we demonstrated an interaction between BMI and Native American ancestry in diabetes risk among women; Native American ancestry was a strong risk factor for diabetes only among overweight and obese women (OR = 1.190 for each 10% increase in Native American ancestry). This study offers new insight into the complex relationship between obesity, genetic ancestry, and their respective effects on diabetes risk. Findings from this study may improve the diabetes risk prediction among Mexican-American individuals thereby facilitating targeted prevention strategies.
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