Evidence map›Paper›PMID 26501384›Full record

ArticleAdvanced healthcare materials2016

Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration.

Hossein K Heris, Jamal Daoud, Sara Sheibani, Hojatollah Vali, Maryam Tabrizian, Luc Mongeau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
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  8. Carbon nanotube composite hydrogels for vocal fold tissue engineering: Biocompatibility, rheology, and porosity.Materials science & engineering. C, Materials for biological applications · 2019
    Article
  9. Review
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  13. A Review of Hyaluronic Acid and Hyaluronic Acid-based Hydrogels for Vocal Fold Tissue Engineering.Journal of voice : official journal of the Voice Foundation · 2017
    Review
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  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hossein K HerisBiomechanics Laboratory, Department of Mechanical Engineering, Faculty of Engineering, McGill University, 817 Rue Sherbrooke Ouest, Montreal, QC, H3A 0C3, Canada.
Jamal DaoudDepartment of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A 2B4, Canada.
Sara SheibaniBiological Threat Defence Section, Defence R&D Canada-Suffield, Station Main, Medicine Hat, AB, T1A 8K6, Canada.
Hojatollah ValiDepartment of Anatomy and Cell Biology, Faculty of Medicine, McGill University, 3640 University Street, Montreal, QC, H3A 0C7, Canada.
Maryam TabrizianDepartment of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC, H3A 2B4, Canada.
Luc MongeauBiomechanics Laboratory, Department of Mechanical Engineering, Faculty of Engineering, McGill University, 817 Rue Sherbrooke Ouest, Montreal, QC, H3A 0C3, Canada.
McGill University · CADefence Research and Development Canada · CA

Funding

Fluid Structure Interactions Within the Human LarynxR01DC005788 · NIDCD · PURDUE UNIVERSITY WEST LAFAYETTE · PI MONGEAU, LUC · 2003 to 2018
$6.4M
NIDCD NIH HHS R01 DC005788NIDCD NIH HHS R01-DC005788
6 · The paper itself

Abstract

The potential use of a novel scaffold biomaterial consisting of cross-linked hyaluronic acid (HA)-gelatin (Ge) composite microgels is investigated for use in treating vocal fold injury and scarring. Cell adhesion integrins and kinematics of cell motion are investigated in 2D and 3D culture conditions, respectively. Human vocal fold fibroblast (hVFF) cells are seeded on HA-Ge microgels attached to a HA hydrogel thin film. The results show that hVFF cells establish effective adhesion to HA-Ge microgels through the ubiquitous expression of β1 integrin in the cell membrane. The microgels are then encapsulated in a 3D HA hydrogel for the study of cell migration. The cells within the HA-Ge microgel-reinforced composite hydrogel (MRCH) scaffold have an average motility speed of 0.24 ± 0.08 μm min(-1) . The recorded microscopic images reveal features that are presumably associated with lobopodial and lamellipodial cell migration modes within the MRCH scaffold. Average cell speed during lobopodial migration is greater than that during lamellipodial migration. The cells move faster in the MRCH than in the HA-Ge gel without microgels. These findings support the hypothesis that HA-Ge MRCH promotes cell adhesion and migration; thereby they constitute a promising biomaterial for vocal fold repair.

Indexed as

ActinsCell AdhesionCell DeathCell MovementCell SurvivalFibroblastsGelatinHumansHyaluronic AcidHydrogel, Polyethylene Glycol DimethacrylatePolyethylene GlycolsRegenerationSulfhydryl CompoundsTissue ScaffoldsVocal CordsActinsGelatinHyaluronic AcidHydrogel, Polyethylene Glycol Dimethacrylatepoly(ethylene glycol)diacrylatePolyethylene GlycolsSulfhydryl Compoundscell adhesion/spreadingcell migration mechanismshyaluronic acid/gelatin hydrogelvocal fold repair

Identifiers

PMID26501384
PMCPMC4885111
OpenAlexW1840671191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.