Evidence map›Paper›PMID 26501363›Full record

ArticleJournal of endocrinological investigation2016

Visceral adiposity is a predictor of parathyroid hormone levels in healthy adults.

J A George, S A Norris, M Toman, T Snyman, N J Crowther

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J A GeorgeDepartment of Chemical Pathology, National Health Laboratory Service and University of the Witwatersrand, Room 3B 41, Third Floor, Medical School, Parktown, Johannesburg, 2193, South Africa. jaya.george@wits.ac.za.
S A NorrisMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
M TomanDepartment of Chemical Pathology, National Health Laboratory Service and University of the Witwatersrand, Room 3B 41, Third Floor, Medical School, Parktown, Johannesburg, 2193, South Africa.
T SnymanDepartment of Chemical Pathology, National Health Laboratory Service and University of the Witwatersrand, Room 3B 41, Third Floor, Medical School, Parktown, Johannesburg, 2193, South Africa.
N J CrowtherDepartment of Chemical Pathology, National Health Laboratory Service and University of the Witwatersrand, Room 3B 41, Third Floor, Medical School, Parktown, Johannesburg, 2193, South Africa.
University of the Witwatersrand · ZANational Health Laboratory Service · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeParathyroid hormone (PTH) has been shown to correlate positively with fat mass, however there are no studies that have investigated whether this association is a result of, or is modified by, body fat distribution. The aim of this study was to investigate the association of PTH with several body composition indices, namely visceral (VAT) and subcutaneous adiposity (SCAT) as well as with lean mass and with serum leptin, which has been reported to increase PTH.

methodsThis was a cross-sectional study in which PTH was measured by chemiluminescent assay; body fat and lean mass by dual-energy X-ray absorptiometry (DXA) and abdominal fat by ultrasonography in 714 healthy adults aged 18-65 years. Serum leptin was measured by ELISA.

resultsIn a multivariate linear regression model that included height, age, gender, ethnicity, serum 25 hydroxyvitamin D, leptin levels, calcium, magnesium and phosphate concentrations, glomerular filtration rate, smoking status, and calcium and vitamin D supplementation as independent variables and PTH as the dependent variable, VAT (β = 0.094, p = 0.035) correlated significantly with PTH levels but SCAT (β = -0.045, p = 0.386) and body fat mass (β = 0.098, p = 0.126) did not. Leptin did not correlate with PTH (β = 0.013, p = 0.832) in this regression model.

conclusionsPlasma PTH is significantly associated with VAT in healthy adults. In view of the association of PTH with increased cardiovascular mortality, it is important to investigate this association further.

Indexed as

AdiposityBody CompositionAbsorptiometry, PhotonAdultBiomarkersCross-Sectional StudiesFemaleFollow-Up StudiesHealthy VolunteersHumansLeptinMaleMiddle AgedObesity, AbdominalParathyroid HormoneThinnessBiomarkersLeptinParathyroid HormoneBody fatParathyroid hormoneVisceral fat

Identifiers

PMID26501363
OpenAlexW2220164096

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.