ArticleNutrients2015
Effects of Dietary Plant Sterols and Stanol Esters with Low- and High-Fat Diets in Chronic and Acute Models for Experimental Colitis.
Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD.Bioscience reports · 2018Trial
- Causal Association of Plasma Lipidome With Inflammatory Bowel Diseases and Mediating Role of Circulating Inflammatory Proteins: A Mendelian Randomization Study.Food science & nutrition · 2025Article
- Industrial Bread Composition: Potential Implications for Patients with Inflammatory Bowel Disease.Nutrients · 2025Review
- Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study.Frontiers in genetics · 2025Article
- The Key Nutrients in the Mediterranean Diet and Their Effects in Inflammatory Bowel Disease: A Narrative Review.Nutrients · 2024Review
- Phytosterols and the Digestive System: A Review Study from Insights into Their Potential Health Benefits and Safety.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy.Scientific reports · 2022Article
- Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea.BMC veterinary research · 2022Article
- Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID).Nutrients · 2021Review
- Intestinal Regulatory T Cells.Advances in experimental medicine and biology · 2021Article
- Article
- Protection of the Ovine Fetal Gut againstNutrients · 2019Article
- Effect of a Milk-Based Fruit Beverage Enriched with Plant Sterols and/or Galactooligosaccharides in a Murine Chronic Colitis Model.Foods (Basel, Switzerland) · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we evaluated the effects of dietary plant sterols and stanols as their fatty acid esters on the development of experimental colitis. The effects were studied both in high- and low-fat diet conditions in two models, one acute and another chronic model of experimental colitis that resembles gene expression in human inflammatory bowel disease (IBD). In the first experiments in the high fat diet (HFD), we did not observe a beneficial effect of the addition of plant sterols and stanols on the development of acute dextran sulphate sodium (DSS) colitis. In the chronic CD4CD45RB T cell transfer colitis model, we mainly observed an effect of the presence of high fat on the development of colitis. In this HFD condition, the presence of plant sterol or stanol did not result in any additional effect. In the second experiments with low fat, we could clearly observe a beneficial effect of the addition of plant sterols on colitis parameters in the T cell transfer model, but not in the DSS model. This positive effect was related to the gender of the mice and on Treg presence in the colon. This suggests that especially dietary plant sterol esters may improve intestinal inflammation in a T cell dependent manner.
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Registered trials
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