ArticleMolecules (Basel, Switzerland)2015
Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- (±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part ofPharmaceutical biology · 2026Article
- Activation of Extraoral Bitter Taste Receptors by Herbs and Spices in the Regulation of Incretin Signaling and Glucose Metabolism.Nutrition reviews · 2026Review
- Discovery of bitter masking compounds from Allspice (Food chemistry: X · 2024Article
- Quantitative Analysis of Isopimpinellin fromMolecules (Basel, Switzerland) · 2024Article
- Methoxyfuranocoumarins of Natural Origin-Updating Biological Activity Research and Searching for New Directions-A Review.Current issues in molecular biology · 2024Review
- Traditional Uses, Phytochemistry, Pharmacology and Toxicology ofDrug design, development and therapy · 2024Review
- Cytotoxic, Anti-Hemolytic, and Antioxidant Activities ofPlants (Basel, Switzerland) · 2023Article
- Article
- Chemoinformatics View on Bitter Taste Receptor Agonists in Food.Journal of agricultural and food chemistry · 2021Article
- Natural Antioxidants from Endemic Leaves in the Elaboration of Processed Meat Products: Current Status.Antioxidants (Basel, Switzerland) · 2021Review
- Essential Oils fromMolecules (Basel, Switzerland) · 2020Article
- Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases.Inflammopharmacology · 2020Review
- G Protein-Coupled Receptors in Taste Physiology and Pharmacology.Frontiers in pharmacology · 2020Review
- Bitter or not? BitterPredict, a tool for predicting taste from chemical structure.Scientific reports · 2017Article
- Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ruta graveolens (rue) is a spontaneous plant in the Mediterranean area with a strong aroma and a very intense bitter taste, used in gastronomy and in folk medicine. From the leaves, stems and fruits of rue, we isolated rutin, rutamarin, three furanocoumarins, two quinolinic alkaloids, a dicoumarin and two long chain ketones. Bitter taste and chemesthetic properties have been evaluated by in vitro assays with twenty receptors of the TAS2R family and four TRP ion channels involved in gustation and nociception. Among the alkaloids, skimmianine was active as a specific agonist of T2R14, whereas kokusaginin did not activate any of the tested receptors. The furanocoumarins activates TAS2R10, 14, and 49 with different degrees of selectivity, as well as the TRPA1 somatosensory ion channel. Rutamarin is an agonist of TRPM5 and TRPV1 and a strong antagonist of TRPM8 ion channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.