Evidence map›Paper›PMID 26501236›Full record

Trial reportInvestigative ophthalmology & visual science2015

Outcome Preferences in Patients With Noninfectious Uveitis: Results of a Best-Worst Scaling Study.

Tsung Yu, Janet T Holbrook, Jennifer E Thorne, Terry N Flynn, Mark L Van Natta, Milo A Puhan

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00132691 (Multicenter Uveitis Steroid Treatment), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00132691 phase4completednot on this map

Multicenter Uveitis Steroid Treatment (MUST) Trial

TypeinterventionalSponsorJHSPH Center for Clinical TrialsRan2005 to 2010Enrolled255ConditionsUveitisArmsfluocinolone acetonide intraocular implant, oral corticosteroid with immunosuppressive agents as needed
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. US Retina Specialists' Preferences for Geographic Atrophy Treatment.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Article
  3. US Patients' Preferences for Geographic Atrophy Treatment.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Tsung YuDepartment of Epidemiology The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States 2Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland.
Janet T HolbrookDepartment of Epidemiology The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States.
Jennifer E ThorneDepartment of Epidemiology The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States 3Department of Ophthalmology/Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United S.
Terry N FlynnCentre for Research Ethics and Bioethics, Uppsala University, Sweden.
Mark L Van NattaDepartment of Epidemiology The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States.
Milo A PuhanEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland.
Johns Hopkins University · USUniversity of Zurich · CHUppsala University · SE

Funding

Multi-Center Uveitis Steriod Treatment (MUST) TrialU10EY014660 · NEI · JOHNS HOPKINS UNIVERSITY · PI HOLBROOK, JANET T. · 2004 to 2016
$33.6M
Multicenter Uveitis Steroid Treatment (MUST) TrialU10EY014655 · NEI · JOHNS HOPKINS UNIVERSITY · PI JABS, DOUGLAS A · 2004 to 2016
$4.6M
Reading Center: Multicenter Uveitis Steroid TrialU10EY014656 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ALTAWEEL, MICHAEL M · 2004 to 2015
$2.2M
NEI NIH HHS EY 014660NEI NIH HHS U10 EY 014655NEI NIH HHS U10 EY014655NEI NIH HHS U10 EY 014656NEI NIH HHS U10 EY014656NEI NIH HHS U10 EY014660
6 · The paper itself

Abstract

purposeTo estimate patient preferences regarding potential adverse outcomes of local versus systemic corticosteroid therapies for noninfectious uveitis by using a best-worst scaling (BWS) approach.

methodsLocal and systemic therapies are alternatives for noninfectious uveitis that have different potential adverse outcomes. Patients participating in the Multicenter Uveitis Steroid Treatment Trial Follow-up Study (MUST FS) and additional patients with a history of noninfectious uveitis treated at two academic medical centers (Johns Hopkins University and University of Pennsylvania) were surveyed about their preferences regarding six adverse outcomes deemed important to patients. Using "case 1" BWS, patients were asked to repeatedly select the most and least worrying from a list of outcomes (in the survey three outcomes per task).

resultsEighty-two patients in the MUST FS and 100 patients treated at the academic medical centers completed the survey. According to BWS, patients were more likely to select vision not meeting the requirement for driving (individual BWS score: median = 3, interquartile range, 0-5), development of glaucoma (2, 1-4), and needing eye surgery (1, 0-3) as the most worrying outcomes as compared to needing medicine for high blood pressure/cholesterol (-2, -4 to 0), development of cataracts (-2, -3 to -1), or infection (sinusitis) (-3, -5 to 0). Larger BWS scores indicated the outcomes were more worrying to patients.

conclusionsPatients with noninfectious uveitis considered impaired vision, development of glaucoma, and need for eye surgery worrying adverse outcomes, which suggests that it is especially desirable to avoid these outcomes if possible. (ClinicalTrials.gov number, NCT00132691.)

Indexed as

Patient PreferenceCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedSurveys and QuestionnairesTreatment OutcomeUveitis

Identifiers

PMID26501236
PMCPMC4627251
OpenAlexW1929654807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.