Observational studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2016
Persistent lymphopenia is an independent predictor of mortality in critically ill emergency general surgical patients.
Observational study in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis.British journal of anaesthesia · 2021Pooled it
- Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.Intensive care medicine · 2019Trial
- Association of red cell distribution width and lymphocyte count with the presence and severity of calcific aortic valve stenosis.Journal of cardiothoracic surgery · 2026Article
- Decreased CD3 + CD4+ T lymphocyte count predicts 28-day all-cause mortality in severe AECOPD patients admitted to the ICU: a retrospective cohort study.Scientific reports · 2026Article
- C-Reactive Protein to Albumin Ratio and Prognostic Nutrition Index as a Predictor of Periprosthetic Joint Infection and Early Postoperative Wound Complications in Patients Undergoing Primary Total Hip and Knee Arthroplasty.Diagnostics (Basel, Switzerland) · 2025Article
- Why should lymphocytes immune profile matter in sepsis?World journal of critical care medicine · 2025Review
- Development of a prediction model for in-hospital mortality in immunocompromised chronic kidney diseases patients with severe infection.BMC nephrology · 2025Article
- Persistent Lymphopenia as a Poor Prognostic Factor in Patients With Multiple Organ Dysfunction Syndrome in the Renal Intensive Care Unit: A Retrospective Single-Center Study.Immunity, inflammation and disease · 2025Observational
- Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy.Frontiers in immunology · 2025Review
- Elevated neutrophil-lymphocyte ratio is associated with high rates of ICU mortality, length of stay, and invasive mechanical ventilation in critically ill patients with COVID-19 : NRL and severe COVID-19.Immunologic research · 2024Article
- Article
- The Controlling Nutritional Status (CONUT) Score for Prediction of Microvascular Flap Complications in Reconstructive Surgery.Journal of clinical medicine · 2023Article
- Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.Military Medical Research · 2022Article
- Major Risk Factors for Mortality in Elderly and Non-Elderly Adult Patients Emergently Admitted for Blunt Chest Wall Trauma: Hospital Length of Stay as an Independent Predictor.International journal of environmental research and public health · 2022Article
- Admission Lymphopenia is Associated With Discharge Disposition in Blunt Chest Wall Trauma Patients.The Journal of surgical research · 2022Article
- Lymphocyte trajectories are associated with prognosis in critically ill patients: A convenient way to monitor immune status.Frontiers in medicine · 2022Article
- The predictive value of prognostic nutritional index on early complications after robot-assisted radical cystectomy.Frontiers in surgery · 2022Article
- Electroacupuncture Attenuates Surgical Stress-Induced Reduction of T Lymphocytes through Modulation of Peripheral Opioid System.Chinese journal of integrative medicine · 2021Article
- Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality.PloS one · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLymphopenia has been associated with poor outcome following sepsis, burns and trauma. This study was designed to establish whether lymphocyte count was associated with mortality in emergency general surgery (EGS) patients, and whether persistent lymphopenia was an independent predictor of mortality.
methodsA retrospective review of a prospectively compiled database of adult patients requiring ICU admission between 2002 and 2013 was performed. EGS patients with acute intra-abdominal pathology and organ dysfunction were included. Lymphocyte counts obtained from the day of ICU admission through to day 7 were examined. Multivariate logistic regression models were used to determine the relationship between persistent lymphopenia and outcome. The primary outcome measure was in-hospital mortality.
resultsThe study included 173 patients, of whom 135 (78 %) had a low lymphocyte count at admission to ICU and 91 % (158/173) developed lymphopenia on at least one occasion. Lymphocyte counts were lower among non-survivors compared with survivors on each day from day 2 (0.62 vs 0.81, p = 0.03) through to day 7 (0.87 vs 1.15, p < 0.01). Patients with a persistently low lymphocyte count during the study period had significantly higher mortality when compared to patients with other lymphocyte patterns (64 vs 29 %, p < 0.01). On multivariate regression analysis, persistent lymphopenia was independently associated with increased in-hospital mortality [odds ratio 3.5 (95 % CI 1.7-7.3), p < 0.01].
conclusionLymphopenia is commonly observed in critically ill EGS patients. Patients with persistent lymphopenia are 3.5 times more likely to die and lymphopenia is an independent predictor of increased mortality in this patient group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.