ArticleJournal of biomechanical engineering2016
Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries.
Article in Journal of biomechanical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Enhanced Properties of Collagen Nanofiber Scaffolds via Chitosan/Polypyrrole/Glutaraldehyde Double-Crosslinking.Membranes · 2026Article
- Three-Dimensional Tissue Strain Measurement Using a Row-Column Array During Biaxial Testing of Excised Ventricular Porcine Myocardium.Ultrasound in medicine & biology · 2025Article
- Synthesis and In Vitro Testing of YVOMolecules (Basel, Switzerland) · 2022Article
- Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications.Pharmaceutics · 2022Review
- Acute Elution of TGFβ2 Affects the Smooth Muscle Cells in a Compliance-Matched Vascular Graft.Tissue engineering. Part A · 2022Article
- In-vivo assessment of a tissue engineered vascular graft computationally optimized for target vessel compliance.Acta biomaterialia · 2021Article
- Bioresorbable silk grafts for small diameter vascular tissue engineering applications: In vitro and in vivo functional analysis.Acta biomaterialia · 2020Article
- Corrugated nanofiber tissue-engineered vascular graft to prevent kinking for arteriovenous shunts in an ovine model.JVS-vascular science · 2020Article
- Multiplatform Protein Detection and Quantification Using Glutaraldehyde-Induced Fluorescence for 3D Systems.Journal of fluorescence · 2019Article
- Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells.Journal of clinical medicine · 2019Article
- Preparation and characterization of small-diameter decellularized scaffolds for vascular tissue engineering in an animal model.Biomedical engineering online · 2017Article
- Stabilisation of Collagen Sponges by Glutaraldehyde Vapour Crosslinking.International journal of biomaterials · 2017Article
- Potential of Electrospun Nanofibers for Biomedical and Dental Applications.Materials (Basel, Switzerland) · 2016Review
- Computationally Optimizing the Compliance of a Biopolymer Based Tissue Engineered Vascular Graft.Journal of biomechanical engineering · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiovascular disease (CVD) is the leading cause of death for Americans. As coronary artery bypass graft surgery (CABG) remains a mainstay of therapy for CVD and native vein grafts are limited by issues of supply and lifespan, an effective readily available tissue-engineered vascular graft (TEVG) for use in CABG would provide drastic improvements in patient care. Biomechanical mismatch between vascular grafts and native vasculature has been shown to be the major cause of graft failure, and therefore, there is need for compliance-matched biocompatible TEVGs for clinical implantation. The current study investigates the biaxial mechanical characterization of acellular electrospun glutaraldehyde (GLUT) vapor-crosslinked gelatin/fibrinogen cylindrical constructs, using a custom-made microbiaxial optomechanical device (MOD). Constructs crosslinked for 2, 8, and 24 hrs are compared to mechanically characterized porcine left anterior descending coronary (LADC) artery. The mechanical response data were used for constitutive modeling using a modified Fung strain energy equation. The results showed that constructs crosslinked for 2 and 8 hrs exhibited circumferential and axial tangential moduli (ATM) similar to that of the LADC. Furthermore, the 8-hrs experimental group was the only one to compliance-match the LADC, with compliance values of 0.0006±0.00018 mm Hg-1 and 0.00071±0.00027 mm Hg-1, respectively. The results of this study show the feasibility of meeting mechanical specifications expected of native arteries through manipulating GLUT vapor crosslinking time. The comprehensive mechanical characterization of cylindrical biopolymer constructs in this study is an important first step to successfully develop a biopolymer compliance-matched TEVG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.