Evidence map›Paper›PMID 26501126›Full record

ArticleACS biomaterials science & engineering2015

Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in

Michael J Kratochvil, Yftah Tal-Gan, Tian Yang, Helen E Blackwell, David M Lynn

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Synthetic Peptides Capable of Potent MultigroupJournal of the American Chemical Society · 2024
    Article
  6. Review
  7. Investigating theMicrobiology (Reading, England) · 2022
    Article
  8. Angewandte Chemie (International ed. in English) · 2022
    Article
  9. Review
  10. Article
  11. Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael J KratochvilDepartment of Chemistry, 1101 University Avenue, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.
Yftah Tal-GanDepartment of Chemistry, 1101 University Avenue, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.
Tian YangDepartment of Chemistry, 1101 University Avenue, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.
Helen E BlackwellDepartment of Chemistry, 1101 University Avenue, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.
David M LynnDepartment of Chemistry, 1101 University Avenue, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States ; Department of Chemical and Biological Engineering, 1415 Engineering Drive, University of Wisconsin - Madison , Madison, Wisconsin 53706, United States.

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Materials and coatings that inhibit bacterial colonization are of interest in a broad range of biomedical, environmental, and industrial applications. In view of the rapid increase in bacterial resistance to conventional antibiotics, the development of new strategies that target nonessential pathways in bacterial pathogens-and that thereby limit growth and reduce virulence through nonbiocidal means-has attracted considerable attention. Bacterial quorum sensing (QS) represents one such target, and is intimately connected to virulence in many human pathogens. Here, we demonstrate that the properties of nanoporous, polymer-based superhydrophobic coatings can be exploited to host and subsequently sustain the extended release of potent and water-labile peptide-based inhibitors of QS (QSIs) in

Indexed as

anti-virulencecontrolled releasepolymer multilayersquorum sensingsuperhydrophobicsurface coatings

Identifiers

PMID26501126
PMCPMC4604486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.