ArticleEBioMedicine2015
Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans.
Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Antibiotic Resistance ofInternational journal of environmental research and public health · 2020Pooled it
- A case of severeRespiratory medicine case reports · 2026Article
- Antimicrobial Susceptibility Determination of Less Frequently IsolatedAntibiotics (Basel, Switzerland) · 2025Article
- Test and treat-impact of microbiological testing on antibiotic prescribing for Legionnaires' disease in Switzerland: results of the multicentre SwissLEGIO study.Pneumonia (Nathan Qld.) · 2025Article
- Antibiotic resistance profiles and mutations that might affect drug susceptibility in metagenome-assembled genomes of Legionella pneumophila and Aeromonas species from municipal wastewater.BMC microbiology · 2025Article
- Two-stage surveillance ofSAGE open medicine · 2025Article
- Omadacycline successfully treated severeFrontiers in pharmacology · 2025Article
- Review
- Antibiotic susceptibility situation of environmentalJournal of water and health · 2024Article
- Antimicrobial Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Atypical pneumonia (Review).Experimental and therapeutic medicine · 2024Review
- Antimicrobial susceptibility testing reveals reduced susceptibility to azithromycin and other antibiotics in Legionella pneumophila serogroup 1 isolates from Portugal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Efficacy of omadacycline in the treatment ofFrontiers in cellular and infection microbiology · 2024Article
- Characteristics of theAntibiotics (Basel, Switzerland) · 2023Article
- The Research Status, Potential Hazards and Toxicological Mechanisms of Fluoroquinolone Antibiotics in the Environment.Antibiotics (Basel, Switzerland) · 2023Review
- Proteome Exploration ofMicrobiology spectrum · 2022Article
- Overview of the Clinical and Molecular Features of Legionella Pneumophila: Focus on Novel Surveillance and Diagnostic Strategies.Antibiotics (Basel, Switzerland) · 2022Review
- Tenets of a holistic approach to drinking water-associated pathogen research, management, and communication.Water research · 2022Review
- The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic.Frontiers in public health · 2022Review
- Link Between Antibiotic Persistence and Antibiotic Resistance in Bacterial Pathogens.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfectious diseases are the leading cause of human morbidity and mortality worldwide. One dramatic issue is the emergence of microbial resistance to antibiotics which is a major public health concern. Surprisingly however, such in vivo adaptive ability has not been reported yet for many intracellular human bacterial pathogens such as Legionella pneumophila.
methodsWe examined 82 unrelated patients with Legionnaire's disease from which 139 respiratory specimens were sampled during hospitalization and antibiotic therapy. We both developed a real time PCR assay and used deep-sequencing approaches to detect antibiotic resistance mutations in L. pneumophila and follow their selection and fate in these samples.
findingsWe identified the in vivo selection of fluoroquinolone resistance mutations in L. pneumophila in two infected patients treated with these antibiotics. By investigating the mutational dynamics in patients, we showed that antibiotic resistance occurred during hospitalization most likely after fluoroquinolone treatment.
interpretationIn vivo selection of antibiotic resistances in L. pneumophila may be associated with treatment failures and poor prognosis. This hidden resistance must be carefully considered in the therapeutic management of legionellosis patients and in the control of the gradual loss of effectiveness of antibiotics.
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