ArticleJournal of clinical and diagnostic research : JCDR2015
Decreased Bone Mineral Density at the Femoral Neck and Lumbar Spine in South Indian Patients with Type 2 Diabetes.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence of osteoporosis in healthy adult males in India measured by dual-energy-X-ray absorptiometry: A systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- The association between glycemic indicators and bone mineral density and osteoporosis: a cross-sectional study.Scientific reports · 2025Article
- Glycemic status and bone health: investigating the impact of glycosylated hemoglobin on bone density in South Indian adults.Journal of diabetes and metabolic disorders · 2024Article
- Prevalence of vertebral fractures and associated factors in thai diabetic postmenopausal women.Scientific reports · 2024Article
- Association between diabetes mellitus and trochanteric bone mineral density in individuals with osteoporotic fractures: a retrospective study.Frontiers in medicine · 2024Article
- Article
- Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018.Frontiers in endocrinology · 2022Article
- The Correlation of Type 2 Diabetes Status with Bone Mineral Density in Middle-Aged Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Assessment of osteoporotic alterations in type 2 diabetes: a retrospective study.Dento maxillo facial radiology · 2017Article
- The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population.Open access Macedonian journal of medical sciences · 2017Article
- Glucose tolerance female-specific QTL mapped in collaborative cross mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Iα2 expression via miR-342.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Crucial Role of Vitamin D in the Musculoskeletal System.Nutrients · 2016Review
- The Expression Level of mRNA, Protein, and DNA Methylation Status ofJournal of diabetes research · 2016Article
- Prevalence of Osteoporosis in Postmenopausal Type 2 Diabetic Women with Diabetic Peripheral Neuropathy.Indian journal of endocrinology and metabolismArticle
- Osteoporosis in Otherwise Healthy Patients with Type 2 Diabetes: A Prospective Gender Based Comparative Study.Indian journal of endocrinology and metabolismArticle
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWith prevalence of diabetes in India reaching epidemic proportions and increase in the population of geriatric age group and risks of falls, it is important to understand the effect that diabetes has on bone health.
aimThe objective was to assess bone mineral density (BMD) of patients with type 2 diabetes mellitus (T2DM) and to study factors contributing to BMD in patients with T2DM. MATERIALS AND
methodsThis was a prospective cross-sectional study on 150 patients with T2DM (diagnosed at age > 30 years) and an equal number (n=150) of age and sex matched healthy controls from September 2012 to July 2014 at a tertiary care center located in Southern India. BMD was measured at the femoral neck and lumbar spine (L2-L4) by dual energy absorptiometry (DXA) in cases and controls. Serum total calcium, phosphorus and alkaline phosphatase (ALP) and 25-OH- vitamin D3 was measured in patient group.
resultsMean age (SD) was 51.29 (±8.05) and 51 (±8.3) years in cases and controls, respectively. The femoral neck and lumbar spine BMD was significantly lower in T2DM cases compared to controls. Also the femoral neck and lumbar spine T-score was significantly lower in T2DM cases compared to controls. Femoral neck BMD among male patients with T2DM was significantly lower compared to controls (men). Among women, BMD at femoral neck as well as lumbar spine was significantly lower in cases when compared to controls. Ninety six out of 150 (64%) T2DM cases had Vitamin D values <20 ng/mL. There was weak negative correlation between age of patient, duration of diabetes and HbA1C with femoral neck BMD. There was weak negative correlation between HbA1C and lumbar spine BMD.
conclusionIndian subjects with type 2 diabetes have significantly lower BMD at both femoral neck and lumbar spine compared to age and sex matched healthy controls. We conclude that osteopenia and osteoporosis are overlooked complications of diabetes. Longitudinal studies are needed to see for actual incidence of fractures among this high risk group.
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