Evidence map›Paper›PMID 26500904›Full record

ArticleJournal of clinical and diagnostic research : JCDR2015

Correlation of Single Nucleotide Polymorphism 35-Kb Upstream of HLA-C and Clinical Profile of Multidrug-Resistant Tuberculosis.

Marwoto, Umi Hani' Vismayanti Lismana, Afiono Agung Prasetyo, Suradi, Reviono, Harsini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

MarwotoA-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Umi Hani' Vismayanti LismanaA-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Afiono Agung PrasetyoA-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Microbiology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia; Center of Biotechnology and Biodiversity Research and Development, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
SuradiDepartment of Pulmonology Faculty of Medicine, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia .
RevionoA-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Pulmonology Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
HarsiniA-Infection Genomic Immunology Cancer (A-IGIC) Research Group, Sebelas Maret University , Jl. Ir. Sutami 36A, Surakarta, Indonesia; Department of Pulmonology, Dr. Moewardi General Hospital, Jl. Kolonel Sutarto 132, Surakarta, Indonesia; Doctoral Program of Medical Sciences Faculty of Medicine, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta, Indonesia .
Sebelas Maret University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe SNP HLA-C-35 kb (rs9264942) may contribute to the host immune defense mechanism by affecting the cell surface expression pattern of HLA-C and antigen presentation to CD8+ cytotoxic cells. Thus, this SNP may contribute to intracellular multidrug-resistant (MDR)-tuberculosis (TB) infection.

aimTo examine the association between the SNP HLA-C-35 kb (rs9264942) and the clinical profile of MDR-TB infection. SETTINGS AND

designMDR-TB-positive patients were followed from May 2012 to December 2013 to observe the progression of MDR-TB infection. Non-TB individuals and non-MDR-TB individuals were also recruited as controls. MATERIALS AND

methodsThe patients' HLA-C-35 kb (rs9264942) status was determined by PCR.

resultsThe C allele was slightly more frequent in the MDR-TB patients than in the non-MDR TB patients (OR= 1.28; 95% CI: 0.701 - 2.328). The C allele was found to be more frequent in the MDR-TB patients exhibiting pulmonary fibrosis (OR= 2.13; 95% CI: 0.606 - 7.480) or pulmonary infiltrates (OR= 3.17; 95% CI: 0.690 - 14.598) and among the MDR-TB patients who were classified as underweight (OR= 8.00; 95% CI: 1.261 - 50.770). The CC genotype was associated with the treatment after failure of category II group (OR= 4.17; 95% CI: 1.301 - 13.346).

conclusionThe C allele SNP HLA-C-35 kb (rs9264942) may contribute to the clinical profile in MDR-TB infection.

Indexed as

Human leukocyte antigen CMajor histocompatibility complex class IRs9264942

Identifiers

PMID26500904
PMCPMC4606233
OpenAlexW2413640194

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.