Evidence map›Paper›PMID 26500740›Full record

ArticleInfectious disease reports2015

Serum 25-Hydroxyvitamin D Levels are not Associated with Adverse Outcomes in Clostridium Difficile Infection.

Dejan Micic, Krishna Rao, Bruno Caetano Trindade, Seth T Walk, Elizabeth Chenoweth, Ruchika Jain, Itishree Trivedi, Kavitha Santhosh, Vincent B Young, David M Aronoff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious disease reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Vitamin DAutophagy · 2022
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dejan MicicDivision of Gastroenterology, Hepatology and Nutrition, University of Chicago , IL, USA.
Krishna RaoDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA ; Division of Infectious Diseases, University of Michigan Health System , Ann Arbor, MI, USA.
Bruno Caetano TrindadeDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA ; Department of Microbiology and Immunology, University of Michigan Health System , Ann Arbor, MI, USA.
Seth T WalkDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA ; Division of Infectious Diseases, University of Michigan Health System , Ann Arbor, MI, USA.
Elizabeth ChenowethUniversity of Michigan Medical School , Ann Arbor, MI, USA.
Ruchika JainDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA ; Division of Infectious Diseases, University of Michigan Health System , Ann Arbor, MI, USA.
Itishree TrivediDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA.
Kavitha SanthoshDepartment of Internal Medicine, University of Michigan Health System , Ann Arbor, MI, USA ; Division of Infectious Diseases, University of Michigan Health System , Ann Arbor, MI, USA.
Vincent B Young
David M Aronoff
Office of Infectious Diseases · USMichigan Medicine · USUniversity of Chicago · USUniversity of Michigan–Ann Arbor · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
The Interplay Between Host Immunity and Clostridium difficile PathogenesisU19AI090871 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B · 2010 to 2014
$7.5M
Phylogenomic epidemiology of Clostridium difficileK01AI097281 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALK, SETH T · 2012 to 2016
$509k
Host and Microbial Biomarkers Related to the Development of Complicated Clostridium difficile InfectionR21AI120599 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B · 2015 to 2016
$426k
NCATS NIH HHS UL1 TR000430NCATS NIH HHS UL1 TR000433NIAID NIH HHS K01 AI097281NIAID NIH HHS R21 AI120599NIAID NIH HHS U19 AI090871NIA NIH HHS P30 AG024824NIDDK NIH HHS P30 DK042086NIDDK NIH HHS T32 DK007074
6 · The paper itself

Abstract

Clostridium difficile infection (CDI) is a significant source of healthcare-associated morbidity and mortality. This study investigated whether serum 25-hydroxyvitamin D is associated with adverse outcomes from CDI. Patients with CDI were prospectively enrolled. Charts were reviewed and serum 25-hydroxyvitamin D was measured. The primary outcome was a composite definition of severe disease: fever (temperature >38°C), acute organ dysfunction, or serum white blood cell count >15,000 cells/µL within 24-48 hours of diagnosis; lack of response to therapy by day 5; and intensive care unit admission; colectomy; or death within 30 days. Sixty-seven patients were included in the final analysis. Mean (±SD) serum 25-hydroxyvitamin D was 26.1 (±18.54) ng/mL. Severe disease, which occurred in 26 (39%) participants, was not associated with serum 25-hydroxyvitamin D [odds ratio (OR) 1.00; 95% confidence interval (CI) 0.96-1.04]. In the adjusted model for severe disease only serum albumin (OR 0.12; 95%CI 0.02-0.64) and diagnosis by detection of stool toxin (OR 5.87; 95%CI 1.09-31.7) remained independent predictors. We conclude that serum 25-hydroxyvitamin D is not associated with the development of severe disease in patients with CDI.

Indexed as

biomarkersClostridium difficilecolitisVitamin D

Identifiers

PMID26500740
PMCPMC4593886
OpenAlexW1785772156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.