ArticleBiotechnology for biofuels2015
Inducible gene expression system by 3-hydroxypropionic acid.
Article in Biotechnology for biofuels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Heterologous production of tungsten-dependent formate dehydrogenase I from Methylorubrum extorquens in Escherichia coli reveals α-subunit maturation as the major bottleneck.Bioresources and bioprocessing · 2026Article
- Genome-Scale Engineering Importing Property of Escherichia coli for Improving Production of 3-Hydroxypropionic Acid.Microbial biotechnology · 2026Article
- Development of an ethanol-based microbial platform for 3-hydroxypropionic acid production using engineered Pseudomonas putida KT2440.Journal of biological engineering · 2025Article
- Genetically encoded biosensors for the circular plastics bioeconomy.Metabolic engineering communications · 2024Article
- Circuit-guided population acclimation of a synthetic microbial consortium for improved biochemical production.Nature communications · 2022Article
- Substrate-inducible and antibiotic-free high-level 4-hydroxyvaleric acid production in engineeredFrontiers in bioengineering and biotechnology · 2022Article
- Inducible and tunable gene expression systems for Pseudomonas putida KT2440.Scientific reports · 2021Article
- Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis.Nature communications · 2021Article
- Levulinic Acid-Inducible and Tunable Gene Expression System forFrontiers in bioengineering and biotechnology · 2021Article
- Transcription Factor Engineering for High-Throughput Strain Evolution and Organic Acid Bioproduction: A Review.Frontiers in bioengineering and biotechnology · 2020Review
- A novel D(-)-lactic acid-inducible promoter regulated by the GntR-family protein D-LldR ofSynthetic and systems biotechnology · 2019Article
- A novel 3-hydroxypropionic acid-inducible promoter regulated by the LysR-type transcriptional activator protein MmsR of Pseudomonas denitrificans.Scientific reports · 2019Article
- The genetic basis of 3-hydroxypropanoate metabolism inBiotechnology for biofuels · 2019Article
- In vivo biosensors: mechanisms, development, and applications.Journal of industrial microbiology & biotechnology · 2018Article
- Engineering an aldehyde dehydrogenase toward its substrates, 3-hydroxypropanal and NADScientific reports · 2017Article
- Production of 3-hydroxypropionic acid in engineered Methylobacterium extorquens AM1 and its reassimilation through a reductive route.Microbial cell factories · 2017Article
- Characterisation of a 3-hydroxypropionic acid-inducible system from Pseudomonas putida for orthogonal gene expression control in Escherichia coli and Cupriavidus necator.Scientific reports · 2017Article
- Measurement of crude-cell-extract glycerol dehydratase activity in recombinant Escherichia coli using coupled-enzyme reactions.Journal of industrial microbiology & biotechnology · 2017Article
- Optimization of industrial microorganisms: recent advances in synthetic dynamic regulators.Journal of industrial microbiology & biotechnology · 2017Review
- Co-production of hydrogen and ethanol from glucose inBiotechnology for biofuels · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background3-Hydroxypropionic acid (3-HP) is an important platform chemical that boasts a variety of industrial applications. Gene expression systems inducible by 3-HP, if available, are of great utility for optimization of the pathways of 3-HP production and excretion.
resultsHere we report the presence of unique inducible gene expression systems in Pseudomonas denitrificans and other microorganisms. In P. denitrificans, transcription of three genes (hpdH, mmsA and hbdH-4) involved in 3-HP degradation was upregulated by 3-HP by the action of a transcriptional regulator protein, LysR, and a cis-acting regulatory site for LysR binding. Similar inducible systems having an LysR transcriptional regulator were identified in other microorganisms that also could degrade 3-HP. A docking study showed that the 3-HP binding pocket is located between the N-terminal helix-turn-helix motif and the C-terminal cofactor-binding domain.
conclusionsThis LysR-regulated 3-HP-inducible system should prove useful for control of the level of gene expression in response to 3-HP.
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