ReviewFrontiers in immunology2015
Microbiota-Specific CD4CD8αα Tregs: Role in Intestinal Immune Homeostasis and Implications for IBD.
Review in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Identification of human DP8α regulatory T cell sub-populations reactive to health-associated anti-inflammatory gut commensals.Gut microbes · 2026Article
- Sex-related peripheral immune profile in ulcerative colitis: links to fatigue.Frontiers in immunology · 2026Article
- Intestinal CD4Nature communications · 2025Article
- Human gut microbiota-reactive DP8α Tregs prevent acute graft-versus-host disease in a CD73-dependent manner.JCI insight · 2024Article
- Single cell analysis revealed that two distinct, unique CD4Frontiers in immunology · 2024Article
- Mechanisms of action and applications ofFrontiers in pharmacology · 2024Review
- Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients.Journal of clinical biochemistry and nutrition · 2023Article
- Review
- CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.The Journal of experimental medicine · 2022Article
- Changes of intestinal microbiota and microbiota-based treatments in IBD.Archives of microbiology · 2022Review
- Human gut microbiota-reactive DP8α regulatory T cells, signature and related emerging functions.Frontiers in immunology · 2022Article
- Intestinal microbiota: a new force in cancer immunotherapy.Cell communication and signaling : CCS · 2020Review
- Mucosal microbial load in Crohn's disease: A potential predictor of response to faecal microbiota transplantation.EBioMedicine · 2020Article
- CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques.Journal of medical primatology · 2019Article
- Article
- CD4CD8αα IELs: They Have Something to Say.Frontiers in immunology · 2019Review
- The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro.PeerJ · 2018Article
- Antigen-specific regulatory T-cell responses to intestinal microbiota.Mucosal immunology · 2017Review
- Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches.Gastroenterology · 2017Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In studies in murine models, active suppression by IL-10-secreting Foxp3 regulatory T cells (Tregs) has emerged as an essential mechanism in colon homeostasis. However, the role of the equivalent subset in humans remains unclear, leading to suggestions that other subsets and/or mechanisms may substitute for Foxp3 Tregs in the maintenance of colon homeostasis. We recently described a new subset of CD4CD8αα T cells reactive to the gut bacterium Faecalibacterium prausnitzii and endowed with regulatory/suppressive functions. This subset is abundant in the healthy colonic mucosa, but less common in that of patients with inflammatory bowel disease (IBD). We discuss here the physiological significance and potential role of these Tregs in preventing inflammation of the gut mucosa and the potential applications of these discoveries for IBD management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.