ArticleFrontiers in microbiology2015
Proteomics identifies Bacillus cereus EntD as a pivotal protein for the production of numerous virulence factors.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Characterization and Genetic Diversity ofMicroorganisms · 2022Article
- TheMicrobiology (Reading, England) · 2021Article
- The Food Poisoning Toxins ofToxins · 2021Review
- Article
- Expression ofMicroorganisms · 2020Article
- Advanced Proteomics as a Powerful Tool for Studying Toxins of Human Bacterial Pathogens.Toxins · 2019Review
- The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis.Frontiers in microbiology · 2019Review
- Time-course proteomics dataset to monitor protein-bound methionine oxidationData in brief · 2018Article
- Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review.International journal of molecular sciences · 2018Review
- Methionine Residues in Exoproteins and Their Recycling by Methionine Sulfoxide Reductase AB Serve as an Antioxidant Strategy inFrontiers in microbiology · 2017Article
- Proteome data to explore the impact of pBClin15 on Bacillus cereus ATCC 14579.Data in brief · 2016Article
- Probiotic Bacillus cereus Strains, a Potential Risk for Public Health in China.Frontiers in microbiology · 2016Article
- Adaptation inFrontiers in microbiology · 2016Review
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5 authors.
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Abstract
Bacillus cereus is a Gram-positive pathogen that causes a wide variety of diseases in humans. It secretes into the extracellular milieu proteins that may contribute directly or indirectly to its virulence. EntD is a novel exoprotein identified by proteogenomics of B. cereus ATCC 14579. We constructed a ΔentD mutant and analyzed the impact of entD disruption on the cellular proteome and exoproteome isolated from early, late, and stationary-phase cultures. We identified 308 and 79 proteins regulated by EntD in the cellular proteome and the exoproteome, respectively. The contribution of these proteins to important virulence-associated functions, including central metabolism, cell structure, antioxidative ability, cell motility, and toxin production, are presented. The proteomic data were correlated with the growth defect, cell morphology change, reduced motility, and reduced cytotoxicity of the ΔentD mutant strain. We conclude that EntD is an important player in B. cereus virulence. The function of EntD and the putative EntD-dependent regulatory network are discussed. To our knowledge, this study is the first characterization of an Ent family protein in a species of the B. cereus group.
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