ArticleFrontiers in behavioral neuroscience2015
Neural correlates of rules and conflict in medial prefrontal cortex during decision and feedback epochs.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.bioRxiv : the preprint server for biology · 2026Article
- Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sex differences in Cingulo-Opercular activation during risky decision-making in youth with externalizing disorders.Psychiatry research. Neuroimaging · 2025Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Impulsive Choices Emerge When the Anterior Cingulate Cortex Fails to Encode Deliberative Strategies.eNeuro · 2024Article
- Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Distinct roles of prefrontal cortex neurons in set shifting.bioRxiv : the preprint server for biology · 2024Article
- Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.Frontiers in neuroscience · 2024Article
- Activation of prefrontal cortex and striatal regions in rats after shifting between rules in a T-maze.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Acute psilocybin enhances cognitive flexibility in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Acute psilocybin enhances cognitive flexibility in rats.bioRxiv : the preprint server for biology · 2023Article
- The GluA1-Related BDNF Pathway Is Involved in PTSD-Induced Cognitive Flexibility Deficit in Attentional Set-Shifting Tasks of Rats.Journal of clinical medicine · 2022Article
- Prelimbic cortex neural encoding dynamically tracks expected outcome value.Physiology & behavior · 2022Article
- Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex.Nature communications · 2022Article
- Dorsomedial prefrontal cortex activation disrupts Pavlovian incentive motivation.Frontiers in behavioral neuroscience · 2022Article
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Article
- Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring.Cell · 2021Article
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2 authors.
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Abstract
The ability to properly adjust behavioral responses to cues in a changing environment is crucial for survival. Activity in the medial Prefrontal Cortex (mPFC) is thought to both represent rules to guide behavior as well as detect and resolve conflicts between rules in changing contingencies. However, while lesion and pharmacological studies have supported a crucial role for mPFC in this type of set-shifting, an understanding of how mPFC represents current rules or detects and resolves conflict between different rules is unclear. Here, we directly address the role of rat mPFC in shifting rule based behavioral strategies using a novel behavioral task designed to tease apart neural signatures of rules, conflict and direction. We demonstrate that activity of single neurons in rat mPFC represent distinct rules. Further, we show increased firing on high conflict trials in a separate population of mPFC neurons. Reduced firing in both populations of neurons was associated with poor performance. Moreover, activity in both populations increased and decreased firing during the outcome epoch when reward was and was not delivered on correct and incorrect trials, respectively. In addition, outcome firing was modulated by the current rule and the degree of conflict associated with the previous decision. These results promote a greater understanding of the role that mPFC plays in switching between rules, signaling both rule and conflict to promote improved behavioral performance.
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