Evidence map›Paper›PMID 26500462›Full record

Trial reportJournal of the International Society of Sports Nutrition2015

A high protein diet (3.4 g/kg/d) combined with a heavy resistance training program improves body composition in healthy trained men and women--a follow-up investigation.

Jose Antonio, Anya Ellerbroek, Tobin Silver, Steve Orris, Max Scheiner, Adriana Gonzalez, Corey A Peacock

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. High-protein diets and testosterone.Nutrition and health · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. High protein consumption in trained women: bad to the bone?Journal of the International Society of Sports Nutrition · 2018
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. The effects of whey protein with or without carbohydrates on resistance training adaptations.Journal of the International Society of Sports Nutrition · 2015
    Trial
  15. Common questions and misconceptions about diets: what does the scientific evidence really show?Journal of the International Society of Sports Nutrition · 2026
    Review
  16. International Society of Sports Nutrition position stand: diets for body weight reduction.Journal of the International Society of Sports Nutrition · 2026
    Review
  17. Article
  18. Article
  19. The Crucial Role of Exercise in Promoting Adolescent Bone Health.Advances in experimental medicine and biology · 2026
    Review
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jose AntonioExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Anya EllerbroekExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Tobin SilverExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Steve OrrisExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Max ScheinerExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Adriana GonzalezExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.
Corey A PeacockExercise and Sports Sciences, Nova Southeastern University, 3532 S. University Drive, University Park Plaza Suite 3532, Davie, FL 33314 USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe consumption of a high protein diet (>4 g/kg/d) in trained men and women who did not alter their exercise program has been previously shown to have no significant effect on body composition. Thus, the purpose of this investigation was to determine if a high protein diet in conjunction with a periodized heavy resistance training program would affect indices of body composition, performance and health.

methodsForty-eight healthy resistance-trained men and women completed this study (mean ± SD; Normal Protein group [NP n = 17, four female and 13 male]: 24.8 ± 6.9 yr; 174.0 ± 9.5 cm height; 74.7 ± 9.6 kg body weight; 2.4 ± 1.7 yr of training; High Protein group [HP n = 31, seven female and 24 male]: 22.9 ± 3.1 yr; 172.3 ± 7.7 cm; 74.3 ± 12.4 kg; 4.9 ± 4.1 yr of training). Moreover, all subjects participated in a split-routine, periodized heavy resistance-training program. Training and daily diet logs were kept by each subject. Subjects in the NP and HP groups were instructed to consume their baseline (~2 g/kg/d) and >3 g/kg/d of dietary protein, respectively.

resultsSubjects in the NP and HP groups consumed 2.3 and 3.4 g/kg/day of dietary protein during the treatment period. The NP group consumed significantly (p < 0.05) more protein during the treatment period compared to their baseline intake. The HP group consumed more (p < 0.05) total energy and protein during the treatment period compared to their baseline intake. Furthermore, the HP group consumed significantly more (p < 0.05) total calories and protein compared to the NP group. There were significant time by group (p ≤ 0.05) changes in body weight (change: +1.3 ± 1.3 kg NP, -0.1 ± 2.5 HP), fat mass (change: -0.3 ± 2.2 kg NP, -1.7 ± 2.3 HP), and % body fat (change: -0.7 ± 2.8 NP, -2.4 ± 2.9 HP). The NP group gained significantly more body weight than the HP group; however, the HP group experienced a greater decrease in fat mass and % body fat. There was a significant time effect for FFM; however, there was a non-significant time by group effect for FFM (change: +1.5 ± 1.8 NP, +1.5 ± 2.2 HP). Furthermore, a significant time effect (p ≤ 0.05) was seen in both groups vis a vis improvements in maximal strength (i.e., 1-RM squat and bench) vertical jump and pull-ups; however, there were no significant time by group effects (p ≥ 0.05) for all exercise performance measures. Additionally, there were no changes in any of the blood parameters (i.e., basic metabolic panel).

conclusionConsuming a high protein diet (3.4 g/kg/d) in conjunction with a heavy resistance-training program may confer benefits with regards to body composition. Furthermore, there is no evidence that consuming a high protein diet has any deleterious effects.

Indexed as

Resistance TrainingAdipose TissueAdolescentAdultBody CompositionBody WeightDietary ProteinsEnergy IntakeFemaleFollow-Up StudiesHumansMaleYoung AdultDietary ProteinsBody CompositionBody FatDietNutritionProtein

Identifiers

PMID26500462
PMCPMC4617900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.