ArticleGenetics and molecular biology
Evolution of flatworm central nervous systems: Insights from polyclads.
Article in Genetics and molecular biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission.Frontiers in molecular neuroscience · 2026Review
- Integrative Taxonomy of Prosogonotrema bilabiatum Vigueras, 1940 (Digenea: Sclerodistomidae): A Parasite in Atlantic Spadefish Chaetodipterus faber (Broussonet, 1782) (Acanthuriformes: Ephippidae) from Brazil.Acta parasitologica · 2024Article
- Model systems for discovering evolutionary singularity of bilaterian physiological regulation: lessons from studies on simple/primitive flatworms.Biophysics and physicobiology · 2024Article
- Evolution of Microglia.Advances in neurobiology · 2024Article
- The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation.Biochemical Society transactions · 2022Review
- Discovery of a body-wide photosensory array that matures in an adult-like animal and mediates eye-brain-independent movement and arousal.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The serotonergic nervous system of prolecithophorans shows a closer similarity to fecampiids than to triclads (Platyhelminthes).Journal of morphology · 2021Article
- Developmental Biology in Central America, the northern region of South America and the Caribbean.The International journal of developmental biology · 2021Review
- The neuroanatomy of the siboglinid Riftia pachyptila highlights sedentarian annelid nervous system evolution.PloS one · 2018Article
- Embracing the comparative approach: how robust phylogenies and broader developmental sampling impacts the understanding of nervous system evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
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Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nervous systems of flatworms have diversified extensively as a consequence of the broad range of adaptations in the group. Here we examined the central nervous system (CNS) of 12 species of polyclad flatworms belonging to 11 different families by morphological and histological studies. These comparisons revealed that the overall organization and architecture of polyclad central nervous systems can be classified into three categories (I, II, and III) based on the presence of globuli cell masses -ganglion cells of granular appearance-, the cross-sectional shape of the main nerve cords, and the tissue type surrounding the nerve cords. In addition, four different cell types were identified in polyclad brains based on location and size. We also characterize the serotonergic and FMRFamidergic nervous systems in the cotylean Boninia divae by immunocytochemistry. Although both neurotransmitters were broadly expressed, expression of serotonin was particularly strong in the sucker, whereas FMRFamide was particularly strong in the pharynx. Finally, we test some of the major hypothesized trends during the evolution of the CNS in the phylum by a character state reconstruction based on current understanding of the nervous system across different species of Platyhelminthes and on up-to-date molecular phylogenies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.