ArticleMolecular physics2012
Mesoscale simulations of curvature-inducing protein partitioning on lipid bilayer membranes in the presence of mean curvature fields.
Article in Molecular physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Computational methods in physical virology: a critical perspective across lengths and timescales.FEMS microbiology reviews · 2026Review
- Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology.Mechanobiology in medicine · 2024Article
- Free energy calculations for membrane morphological transformations and insights to physical biology and oncology.Methods in enzymology · 2024Article
- A Review of Mechanics-Based Mesoscopic Membrane Remodeling Methods: Capturing Both the Physics and the Chemical Diversity.The Journal of membrane biology · 2022Review
- Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness.iScience · 2022Article
- Quantification of Curvature Sensing Behavior of Curvature-Inducing Proteins on Model Wavy Substrates.The Journal of membrane biology · 2022Article
- Nonaxisymmetric Shapes of Biological Membranes from Locally Induced Curvature.Biophysical journal · 2020Article
- Entry modes of ellipsoidal nanoparticles on a membrane during clathrin-mediated endocytosis.Soft matter · 2019Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Thermodynamic free energy methods to investigate shape transitions in bilayer membranes.International journal of advances in engineering sciences and applied mathematics · 2016Article
- Multiscale computational models in physical systems biology of intracellular trafficking.IET systems biology · 2014Article
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Defining the free-energy landscape of curvature-inducing proteins on membrane bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- LipidWrapper: an algorithm for generating large-scale membrane models of arbitrary geometry.PLoS computational biology · 2014Article
- Multiscale perspectives of virus entry via endocytosis.Virology journal · 2013Review
- Article
- Phenomenology based multiscale models as tools to understand cell membrane and organelle morphologies.Advances in planar lipid bilayers and liposomesArticle
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5 authors.
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Abstract
The membrane-surface migration of curvature-inducing proteins in response to membrane curvature gradients has been investigated using Monte Carlo simulations of a curvilinear membrane model based on the Helfrich Hamiltonian. Consistent with theoretical and experimental data, we find the proteins that generate curvature can also sense the background membrane curvature, wherein they preferentially partition to the high curvature regions. The partitioning strength depends linearly on local membrane curvature and the slope (or the coupling constant) of the partitioning probability versus mean curvature depends on the membrane bending rigidity and instantaneous curvature field caused by different proteins. Our simulation study allows us to quantitatively characterize and identify the important factors affecting the coupling constant (slope), which may be difficult to determine in experiments. Furthermore, the membrane model is used to study budding of vesicles where it is found that in order to stabilize a mature vesicle with a stable 'neck-region' (or stable membrane overhangs), the area (extent) of the intrinsic curvature region needs to exceed a threshold-critical value. The migration and partitioning of curvature-inducing proteins in a budding vesicle with a stable neck (with a characteristic negative value of the Gaussian curvature) is investigated.
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