SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2015
The association between symptoms and bladder or renal tract cancer in primary care: a systematic review.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Clinical practice guidelines for molecular tumor marker, 2nd edition review part 2.International journal of clinical oncology · 2024Guideline
- Risk prediction models for symptomatic patients with bladder and kidney cancer: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Pooled it
- Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
- Aspirin or non-steroidal anti-inflammatory drug initiation and subsequent bladder cancer evaluation.Journal of internal medicine · 2026Article
- Symptoms and signs of urogenital cancer in primary care.BMC primary care · 2023Article
- The vascular and morphological characteristics of tumors under narrow-band imaging as predictors for the grade and stage of bladder cancer: a prospective and multi-center study.Annals of medicine · 2023Article
- Nurse-led one stop hematuria clinic: Outcomes from 2,714 patients.BJUI compass · 2021Article
- A Fact-Finding Procedure Integrating Machine Learning and AHP Technique to Predict Delayed Diagnosis of Bladder Patients with Hematuria.Journal of healthcare engineering · 2021Article
- Hematuria in aging men with hemophilia: Association with factor prophylaxis.Research and practice in thrombosis and haemostasis · 2020Article
- Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care.Advances in therapy · 2019Article
- Evaluation of Hospital-Based Hematuria Diagnosis and Subsequent Cancer Risk Among Adults in Denmark.JAMA network open · 2018Article
- Symptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence.Neoplasia (New York, N.Y.) · 2018Review
- Haematuria in ADPKD: not always benign. Be aware!BMJ case reports · 2017Article
- Application of Electronic Algorithms to Improve Diagnostic Evaluation for Bladder Cancer.Applied clinical informatics · 2017Article
- Fast-track access to urologic care for patients with macroscopic haematuria is efficient and cost-effective: results from a prospective intervention study.British journal of cancer · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppropriate selection for further investigation of patients presenting in primary care with symptoms that may indicate cancer is key to early diagnosis.
aimTo quantify the risk of urinary tract cancer in patients presenting in primary care with symptoms that may indicate bladder or renal cancer. DESIGN AND
settingSystematic review of studies relating to bladder or renal cancer in primary care.
methodDatabases searched were MEDLINE, PreMEDLINE, Embase, the Cochrane Library, Web of Science (SCI and SSCI), and ISI Proceedings from 1980 to August 2014, and PsycINFO (1980-2012) and BioMed Central (inception to 2012) for retrospective, prospective, or case-control diagnostic accuracy studies of symptomatic patients presenting to primary care with one or more symptoms for whom follow-up data were available. The target conditions were bladder or renal cancer. The studies were appraised using the QUADAS-2 tool.
resultsEleven studies with 3 451 675 patients were included. The positive predictive value (PPV) from meta-analysis of visible haematuria was 5.1% in adult patients. It increased with age and was higher in males. The PPVs of other single symptoms were very low, with the highest non-haematuria PPV being 1.4% for anaemia in males. Fewer data were available on the PPVs of symptom combinations. Generally, these data showed that, with the exception of symptom combinations including haematuria, these were very low.
conclusionThe only high-risk feature of bladder/renal cancer in primary care was visible haematuria, and this clearly warrants investigation. However, not all patients with one of these cancers experience haematuria, so a policy restricting investigation to patients with haematuria will inevitably delay the diagnosis in some patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.