Evidence map›Paper›PMID 26500257›Full record

ArticleGenetics2016

Deep History of East Asian Populations Revealed Through Genetic Analysis of the Ainu.

Choongwon Jeong, Shigeki Nakagome, Anna Di Rienzo

Abstract read
In one paragraph

Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Choongwon JeongDepartment of Human Genetics, University of Chicago, Chicago, Illinois 60615.
Shigeki NakagomeDepartment of Human Genetics, University of Chicago, Chicago, Illinois 60615 Department of Mathematical Analysis and Statistical Inference, The Institute of Statistical Mathematics, Tokyo, Japan, 190-8562 dirienzo@bsd.uchicago.edu snakagome@bsd.uchicago.edu.
Anna Di RienzoDepartment of Human Genetics, University of Chicago, Chicago, Illinois 60615 dirienzo@bsd.uchicago.edu snakagome@bsd.uchicago.edu.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Genetic adaptations to high altitudeR01HL119577 · NHLBI · UNIVERSITY OF CHICAGO · PI DI RIENZO, ANNA · 2014 to 2023
$4.9M
Beagle-2S10OD018495 · OD · UNIVERSITY OF CHICAGO · PI FOSTER, IAN · 2014 to 2014
$2.0M
NCATS NIH HHS UL1 TR000430NHLBI NIH HHS R01 HL119577NHLBI NIH HHS R01HL119577NIH HHS 1S10OD018495-01NIH HHS S10 OD018495
6 · The paper itself

Abstract

Despite recent advances in population genomics, much remains to be elucidated with regard to East Asian population history. The Ainu, a hunter-gatherer population of northern Japan and Sakhalin island of Russia, are thought to be key to elucidating the prehistory of Japan and the peopling of East Asia. Here, we study the genetic relationship of the Ainu with other East Asian and Siberian populations outside the Japanese archipelago using genome-wide genotyping data. We find that the Ainu represent a deep branch of East Asian diversity more basal than all present-day East Asian farmers. However, we did not find a genetic connection between the Ainu and populations of the Tibetan plateau, rejecting their long-held hypothetical connection based on Y chromosome data. Unlike all other East Asian populations investigated, the Ainu have a closer genetic relationship with northeast Siberians than with central Siberians, suggesting ancient connections among populations around the Sea of Okhotsk. We also detect a recent genetic contribution of the Ainu to nearby populations, but no evidence for reciprocal recent gene flow is observed. Whole genome sequencing of contemporary and ancient Ainu individuals will be helpful to understand the details of the deep history of East Asians.

Indexed as

AllelesAsian PeopleGene FlowGene FrequencyGenetic HeterogeneityGenome, HumanGenotypeHumansJapanPolymorphism, Single NucleotideRussiaSiberiademographyJomonmigrationTibet

Identifiers

PMID26500257
PMCPMC4701090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.