ArticleBiology open2015
Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation.
Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Genomic Insights Into the Body Size Evolution in Felidae (Mammalia: Carnivora).Ecology and evolution · 2026Article
- Correlation between inner epiphysis ulna radius length ratio and prognosis of Monteggia fractures in children: a multicenter study.Scientific reports · 2025Article
- Whole-genome resequencing infers genomic basis of giant phenotype in Siamese fighting fish (Zoological research · 2022Article
- Effects of maternal consumption of morphine on rat skeletal system development.BMC musculoskeletal disorders · 2021Article
- The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss ofFrontiers in cell and developmental biology · 2021Article
- Mechanisms of bone development and repair.Nature reviews. Molecular cell biology · 2020Review
- Article
- Complex Phenotypes: Mechanisms Underlying Variation in Human Stature.Current osteoporosis reports · 2019Review
- Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life.Nature communications · 2019Article
- Article
- HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system.The International journal of developmental biology · 2018Article
- Hox11 Function Is Required for Region-Specific Fracture Repair.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Hox genes in the adult skeleton: Novel functions beyond embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells.Developmental cell · 2016Article
- Accumulation of transposable elements in Hox gene clusters during adaptive radiation of Anolis lizards.Proceedings. Biological sciences · 2016Article
- Hox genes and evolution.F1000Research · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are necessary for appendicular development along the proximal to distal axis. Loss of function of both Hoxa11 and Hoxd11 results in severe malformation of the forelimb zeugopod. In the radius and ulna of these mutants, chondrocyte development is perturbed, growth plates are not established, and skeletal growth and maturation fails. In compound mutants in which one of the four Hox11 alleles remains wild-type, establishment of a growth plate is preserved and embryos develop normally through newborn stages, however, skeletal phenotypes become evident postnatally. During postnatal development, the radial and ulnar growth rate slows compared to wild-type controls and terminal bone length is reduced. Growth plate height is decreased in mutants and premature growth plate senescence occurs along with abnormally high levels of chondrocyte proliferation in the reserve and proliferative zones. Compound mutants additionally develop an abnormal curvature of the radius, which causes significant distortion of the carpal elements. The progressive bowing of the radius appears to result from physical constraint caused by the disproportionately slower growth of the ulna than the radius. Collectively, these data are consistent with premature depletion of forelimb zeugopod progenitor cells in the growth plate of Hox11 compound mutants, and demonstrate a continued function for Hox genes in postnatal bone growth and patterning.
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Registered trials
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