Evidence map›Paper›PMID 26500184›Full record

ArticleEuropean journal of obstetrics, gynecology, and reproductive biology2015

Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery.

Marit P Martinussen, Michael B Bracken, Elizabeth W Triche, Geir W Jacobsen, Kari R Risnes

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of obstetrics, gynecology, and reproductive biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  18. Immunology of hepatic diseases during pregnancy.Seminars in immunopathology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Marit P MartinussenDepartment of Obstetrics and Gynecology, St. Olav's University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: marit.martinussen@ntnu.no.
Michael B BrackenYale Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University, New Haven, CT, USA.
Elizabeth W TricheMandell Center for Multiple Sclerosis and Neuroscience Research, Mount Sinai Rehabilitation Hospital, St. Francis Care, Hartford, CT, USA.
Geir W JacobsenDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Kari R RisnesDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Pediatrics, St. Olav's University Hospital, Trondheim, Norway.
Norwegian University of Science and Technology · NOMount Sinai Rehabilitation Hospital · USProvidence Center · USSt Olav's University Hospital · NO

Funding

Perinatal Risk of Asthma in Infants of Asthmatic MothersR01AI041040 · NIAID · YALE UNIVERSITY · PI BRACKEN, MICHAEL B · 1996 to 2007
$3.8M
Paraxanthine and Reproductive Effects of CaffeineR01DA005484 · NIDA · YALE UNIVERSITY · PI BRACKEN, MICHAEL B · 1987 to 2004
$684k
NIAID NIH HHS R01 AI041040NIAID NIH HHS R01AI041040NIDA NIH HHS R01 DA005484NIDA NIH HHS R01DA005484
6 · The paper itself

Abstract

objectiveTo assess whether folic acid intake during the first trimester of pregnancy is related to pregnancy outcomes preeclampsia, low birth weight or preterm birth. STUDY

designProspective cohort study of 3647 women who were followed from the first trimester of pregnancy. Detailed information on quantity of folic acid intake before and during the first three months of pregnancy was recorded. Pregnancy outcome data were abstracted from obstetric records.

resultsLean mothers who used folic acid supplementation the month before pregnancy had a 40% reduced risk of developing preeclampsia. The adjusted odds ratio (OR) with 95% confidence intervals (95%CI) for preeclampsia in lean mothers (BMI<25) who used folic acid supplements the month before pregnancy was 0.6 (95% CI 0.4-1.0). Obese mothers who used folic acid supplementation in the first trimester had an increased, but not statistically significant risk for preterm birth (adjusted OR 1.9 with 95% CI 0.9-4.0). There were no significant associations between folic acid supplementation and low birth weight.

conclusionOur study supports a possible protective effect of folate intake in early pregnancy on preeclampsia in lean mothers. There was no support for any beneficial effect of folic acid use on preterm birth or low birth weight, and we found no evidence of any harmful effects of folate use for the outcomes included in our study.

Indexed as

AdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesFolic AcidVitamin B ComplexFolic acidLow birth weightPreeclampsiaPreterm labor

Identifiers

PMID26500184
PMCPMC4684439
OpenAlexW1942742095

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.