Trial reportBMC cancer2015
A randomized controlled trial of web-based cognitive behavioral therapy for severely fatigued breast cancer survivors (CHANGE-study): study protocol.
Trial report in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Efficacy of Mindfulness-Based Interventions for Reducing Cancer-Related Fatigue: A Systematic Review and Meta-Analysis.Psycho-oncology · 2026Pooled it
- Home-based multidimensional survivorship programmes for breast cancer survivors.The Cochrane database of systematic reviews · 2017Pooled it
- The Effect of Internet-Based Cognitive Behavioral Therapy (I-CBT) for Severe Fatigue in Adolescents with Immune Dysregulation Disorders: Preliminary Findings using a Multiple Single-Case Experimental Design.Journal of clinical psychology in medical settings · 2026Trial
- Trial
- What is needed for improved uptake and adoption of digital aftercare programs by cancer survivors: a mixed methods study applying the COM-B model.Journal of cancer survivorship : research and practice · 2026Article
- Development and testing of a videogame intervention for symptom management among 8-18 years old children with cancer: a study protocol.BMJ paediatrics open · 2024Article
- Web-Based Cognitive-Behavioral Therapy to Reduce Severe Cancer-Related Fatigue Among Survivors of Hodgkin Lymphoma: A Feasibility Study.Journal of clinical psychology in medical settings · 2023Article
- Patient preference attributes in eHealth interventions for cancer-related fatigue: A scoping review.European journal of cancer care · 2022Article
- A conceptual disease model for quality of life in mitochondrial disease.Orphanet journal of rare diseases · 2022Article
- eHealth Interventions for Dutch Cancer Care: Systematic Review Using the Triple Aim Lens.JMIR cancer · 2022Review
- Stepped-care cognitive behaviour therapy program for treating cancer-related fatigue: protocol for a feasibility study.Pilot and feasibility studies · 2022Article
- A pilot study of cognitive behavioural therapy integrated with activity pacing for fatigued breast cancer patients undergoing chemotherapy in Ethiopia.Frontiers in oncology · 2022Article
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- Article
- Article
- Personalizing cognitive behavioral therapy for cancer-related fatigue using ecological momentary assessments followed by automated individual time series analyses: A case report series.Internet interventions · 2021Article
- Article
- Cancer-related fatigue and its determinants in a cohort of women with breast cancer: the DAMA Cohort.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Study Protocol of CBT-AP Trial: A Randomized Controlled Trial of Cognitive Behavioral Therapy Integrated with Activity Pacing for Fatigued Breast Cancer Patients Undergoing Chemotherapy.Integrative cancer therapiesArticle
- Patient-reported distress and survival among patients receiving definitive radiation therapy.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbout one third of breast cancer survivors suffer from persistent severe fatigue after completion of curative cancer treatment. Face-to-face cognitive behavioral therapy (F2F CBT), especially designed for fatigue in cancer survivors, was found effective in reducing fatigue. However, this intervention is intensive and treatment capacity is limited. To extend treatment options, a web-based version of CBT requiring less therapist time was developed. This intervention is aimed at changing fatigue-perpetuating cognitions and behaviors. The efficacy of web-based CBT will be examined in a multicenter randomized controlled trial.
methodsIn total, 132 severely fatigued breast cancer survivors will be recruited and randomized to either an intervention condition or care as usual (ratio 1:1). Participants will be assessed at baseline and 6 months thereafter. The intervention group will receive web-based CBT, consisting of three F2F sessions and maximally eight web-based modules over a period of 6 months. The care as usual group will be on a waiting list for regular F2F CBT. The total duration of the waiting list is 6 months. The primary outcome of the study is fatigue severity. Secondary outcomes are functional impairments, psychological distress and quality of life. DISCUSSION: If web-based CBT is effective, it will provide an additional treatment option for fatigue in breast cancer survivors. Web-based CBT is expected to be less time-consuming for therapists than regular F2F CBT, which would result in an increased treatment capacity. Moreover, the intervention would become more easily accessible for a larger number of patients, and patients can save travel time and costs.
trial registrationDutch Trial Registry--NTR4309.
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