Evidence map›Paper›PMID 26499941›Full record

ArticleAesthetic surgery journal2016

Interaction Between Breast Cancer Cells and Adipose Tissue Cells Derived from Fat Grafting.

Michela Massa, Simona Gasparini, Ilaria Baldelli, Linda Scarabelli, Pierluigi Santi, Rodolfo Quarto, Erica Repaci

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aesthetic surgery journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Adipocytes secretome from normal and tumor breast favor breast cancer invasion by metabolic reprogramming.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michela MassaDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Simona GaspariniDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Ilaria BaldelliDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Linda ScarabelliDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Pierluigi SantiDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Rodolfo QuartoDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Erica RepaciDr Massa is a Plastic Surgeon and Fellow, Dr Baldelli is a Plastic Surgeon and Assistant Professor, and Dr Santi is a Plastic Surgeon and Full Professor, Department of Integrated Surgical and Diagnostic Sciences, University of Genoa, IRCCS San Martino IST, Genoa, Italy. Ms Gasparini is a Researcher and Fellow, Ms Scarabelli is a Researcher, Dr Quarto is a Researcher and Full Professor, and Dr Repaci is a Researcher and Fellow, Department of Experimental Medicine, University of Genoa, Genoa, Italy.
University of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipose tissue transplantation has the benefit of providing both regenerative and aesthetic outcomes in breast cancer treatment. However, the transplanted tissue can stimulate the growth of residual cancer cells.

objectivesThe aim of this study is to identify the interactions between adipose tissue cell subpopulations and human cancer cell lines.

methodsIntact adipose tissue from lipofilling procedures as well as fibroblasts derived from adipose tissue, were cocultured in the presence of MDA-MB-231, MCF-7 e ZR-75-1 breast cancer cell lines. The influence on cancer cell lines of fibroblasts, induced to differentiate into specific adipocytes, was also assayed.

resultsAll cancer cell lines displayed a significant increase in proliferation rate when cocultured in the presence of either intact adipose tissue or induced adipocytes. To a lesser extent, uninduced fibroblasts stimulate breast cancer cell proliferation.

conclusionsRecent studies have shown that the microenvironment surrounding breast cancer cells may stimulate growth and promote progression of residual cancer cells when surgery is performed on the main tumor mass. Accordingly, the graft of adipose tissue could potentially promote or accelerate the development of a subclinical tumor or support its locoregional recurrence. Our data suggest that adipocytes have a remarkable influence on the proliferation of cancer cell lines. The oncological safety of the lipofilling procedure outcome is still debated; thus, further studies and consistent follow-up examination are needed.

Indexed as

AdipogenesisCell CommunicationCell TransdifferentiationAdipocytesAdipose TissueAdultBreast NeoplasmsCell ProliferationCoculture TechniquesFemaleFibroblastsHumansMCF-7 CellsMiddle AgedPhenotype

Identifiers

PMID26499941
PMCPMC5127459
OpenAlexW2246690245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.