Trial reportBMC neurology2015
Do cognitive measures and brain circuitry predict outcomes of exercise in Parkinson Disease: a randomized clinical trial.
Trial report in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02231073 (Peripheral and Central Postural Disorders in the Elderly), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peripheral and Central Postural Disorders in the Elderly
Who cites it
19 citing papers in PubMed.
- Early implementation of intended exercise improves quality of life in Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Trial
- Association between plasma dipeptidyl peptidase-4 levels and cognitive function in perinatal pregnant women with gestational diabetes mellitus.World journal of clinical cases · 2021Trial
- Cortical thickness as predictor of response to exercise in people with Parkinson's disease.Human brain mapping · 2021Trial
- Cognitively Challenging Agility Boot Camp Program for Freezing of Gait in Parkinson Disease.Neurorehabilitation and neural repair · 2020Trial
- Effects of 2 Years of Exercise on Gait Impairment in People With Parkinson Disease: The PRET-PD Randomized Trial.Journal of neurologic physical therapy : JNPT · 2017Trial
- Dancing through time: Cognitive changes over six years of community dance in Parkinson's disease.Journal of Alzheimer's disease : JAD · 2026Observational
- Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson's Disease: A Coordinated Analysis.Neurorehabilitation and neural repair · 2025Article
- Article
- Effects of a Cognitively Challenging Agility Boot Camp Program on Balance and Gait in People With Parkinson's Disease: Does Freezing of Gait Status Matter?Neurorehabilitation and neural repair · 2022Article
- Inertial Sensor Algorithms to Characterize Turning in Neurological Patients With Turn Hesitations.IEEE transactions on bio-medical engineering · 2021Article
- Effects of the agility boot camp with cognitive challenge (ABC-C) exercise program for Parkinson's disease.NPJ Parkinson's disease · 2020Article
- Relating Parkinson freezing and balance domains: A structural equation modeling approach.Parkinsonism & related disorders · 2020Article
- Structured Care and Self-Management Education for Persons with Parkinson's Disease: Why the First Does Not Go without the Second-Systematic Review, Experiences and Implementation Concepts from Sweden and Germany.Journal of clinical medicine · 2020Article
- The New Freezing of Gait Questionnaire: Unsuitable as an Outcome in Clinical Trials?Movement disorders clinical practice · 2020Article
- Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease.Frontiers in neurology · 2020Article
- Towards understanding neural network signatures of motor skill learning in Parkinson's disease and healthy aging.The British journal of radiology · 2019Review
- How to Select Balance Measures Sensitive to Parkinson's Disease from Body-Worn Inertial Sensors-Separating the Trees from the Forest.Sensors (Basel, Switzerland) · 2019Article
- Pharmacological treatment in Parkinson's disease: Effects on gait.Parkinsonism & related disorders · 2016Review
- Impaired Retention of Motor Learning of Writing Skills in Patients with Parkinson's Disease with Freezing of Gait.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThere is emerging research detailing the relationship between balance/gait/falls and cognition. Imaging studies also suggest a link between structural and functional changes in the frontal lobe (a region commonly associated with cognitive function) and mobility. People with Parkinson's disease have important changes in cognitive function that may impact rehabilitation efficacy. Our underlying hypothesis is that cognitive function and frontal lobe connections with the basal ganglia and brainstem posture/locomotor centers are responsible for postural deficits in people with Parkinson's disease and play a role in rehabilitation efficacy. The purpose of this study is to 1) determine if people with Parkinson's disease can improve mobility and/or cognition after partaking in a cognitively challenging mobility exercise program and 2) determine if cognition and brain circuitry deficits predict responsiveness to exercise rehabilitation. METHODS/
designThis study is a randomized cross-over controlled intervention to take place at a University Balance Disorders Laboratory. The study participants will be people with Parkinson's disease who meet inclusion criteria for the study. The intervention will be 6 weeks of group exercise (case) and 6 weeks of group education (control). The exercise is a cognitively challenging program based on the Agility Boot Camp for people with PD. The education program is a 6-week program to teach people how to better live with a chronic disease. The primary outcome measure is the MiniBESTest and the secondary outcomes are measures of mobility, cognition and neural imaging. DISCUSSION: The results from this study will further our understanding of the relationship between cognition and mobility with a focus on brain circuitry as it relates to rehabilitation potential.
trial registrationThis trial is registered at clinical trials.gov (NCT02231073).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.