ArticleNeuroImage2016
The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Role of White Matter Microstructure in Impulsive Behavior.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.Human brain mapping · 2016Pooled it
- Randomized double-blind inpatient study of a gluten-free diet for negative symptoms in people with schizophrenia.Schizophrenia research · 2026Trial
- Sparse Multivariate Analysis Reveals Dissociable White Matter Networks for Cognitive and Motor Processing Speed.Brain sciences · 2026Article
- Glymphopathy and Reduced Processing Speed in Community-Dwelling Adults with Silent Cerebral Small Vessel Disease: A DTI-ALPS Study.Journal of clinical medicine · 2025Article
- A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.Human brain mapping · 2024Article
- Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study.Brain sciences · 2024Article
- Mediation Analysis for High-Dimensional Mediators and Outcomes with an Application to Multimodal Imaging Data.Computational statistics & data analysis · 2023Article
- Metabolic syndrome predictors of brain gray matter volume in an age-stratified community sample of 776 Mexican- American adults: Results from the genetics of brain structure image archive.Frontiers in aging neuroscience · 2022Article
- White Matter Microstructure across the Psychosis Spectrum.Trends in neurosciences · 2020Review
- Estimating the heritability of psychological measures in the Human Connectome Project dataset.PloS one · 2020Article
- Shared genetic influences on adolescent body mass index and brain structure: A voxel-based morphometry study in twins.NeuroImage · 2019Article
- Clinical and genetic validity of quantitative bipolarity.Translational psychiatry · 2019Article
- Genomic kinship construction to enhance genetic analyses in the human connectome project data.Human brain mapping · 2019Article
- Homogenizing Estimates of Heritability Among SOLAR-Eclipse, OpenMx, APACE, and FPHI Software Packages in Neuroimaging Data.Frontiers in neuroinformatics · 2019Article
- Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline.Human brain mapping · 2018Article
- Local connectome phenotypes predict social, health, and cognitive factors.Network neuroscience (Cambridge, Mass.) · 2018Article
- Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia.JAMA psychiatry · 2017Article
- Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia.Genes, brain, and behavior · 2017Article
- Specificity of executive functioning and processing speed problems in common psychopathology.Neuropsychology · 2017Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
Speed with which brain performs information processing influences overall cognition and is dependent on the white matter fibers. To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations. Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP). The heritability of processing speed was h(2)=43% and 49% (both p<0.005), while the heritability of whole brain FA was h(2)=87% and 88% (both p<0.001), in the OOA and HCP, respectively. Whole brain FA was significantly correlated with processing speed in the two cohorts. Quantitative genetic analysis demonstrated a significant degree to which common genes influenced joint variation in FA and brain processing speed. These estimates suggested common sets of genes influencing variation in both phenotypes, consistent with the idea that common genetic variations contributing to white matter may also support their associated cognitive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.