Trial reportRadiation oncology (London, England)2015
Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study.
Trial report in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02212548 (Prostate-Rectal Separation With PEG Hydrogel and Its Effect on Decreasing Rectal Dose), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prostate-Rectal Separation With PEG Hydrogel and Its Effect on Decreasing Rectal Dose
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of rectal displacement devices in managing prostate motion: a systematic review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Pooled it
- Multicenter, dual fractionation scheme, single core lab comparison of rectal volume dose reduction following injection of two biodegradable perirectal spacers.Journal of applied clinical medical physics · 2023Trial
- Impact of intrafraction fiducial tracking on planning target margins during prostate stereotactic body radiotherapy using Brainlab ExacTrac Dynamic with robotic couch correction.Journal of applied clinical medical physics · 2025Article
- Article
- Dose evaluation of inter- and intra-fraction prostate motion in extremely hypofractionated intensity-modulated proton therapy for prostate cancer.Physics and imaging in radiation oncology · 2023Article
- Intra-prostatic gold fiducial marker insertion for image-guided radiotherapy (IGRT): five-year experience on 795 patients.BMC medical imaging · 2023Article
- Dosimetric comparison of MR-guided adaptive IMRT versus 3DOF-VMAT for prostate stereotactic radiotherapy.Technical innovations & patient support in radiation oncology · 2022Article
- Injection of hydrogel spacer increased maximal intrafractional prostate motion in anterior and superior directions during volumetric modulated arc therapy-stereotactic body radiation therapy for prostate cancer.Radiation oncology (London, England) · 2022Article
- Dosimetric effects of quality assurance-related setup errors in passive proton therapy for prostate cancer with and without a hydrogel spacer.Radiological physics and technology · 2021Article
- Quantifying the impact of SpaceOAR hydrogel on inter-fractional rectal and bladder dose during 0.35 T MR-guided prostate adaptive radiotherapy.Journal of applied clinical medical physics · 2021Article
- Preliminary analysis of prostate positional displacement using hydrogel spacer during the course of proton therapy for prostate cancer.Journal of radiation research · 2021Article
- Clinical effects of rectal retractor application in prostate cancer radiotherapy.Medical journal of the Islamic Republic of Iran · 2021Article
- Article
- In regard to Cuccia et al.: impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy.Radiation oncology (London, England) · 2020Article
- Effect of a hydrogel spacer on the intrafractional prostate motion during CyberKnife treatment for prostate cancer.Journal of applied clinical medical physics · 2020Article
- Impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy.Radiation oncology (London, England) · 2020Article
- respiTrack: Patient-specific real-time respiratory tumor motion prediction using magnetic tracking.International journal of computer assisted radiology and surgery · 2020Article
- CBCT evaluation of inter- and intra-fraction motions during prostate stereotactic body radiotherapy: a technical note.Radiation oncology (London, England) · 2020Article
- Hydrogels Based Drug Delivery Synthesis, Characterization and Administration.Pharmaceutics · 2019Review
- A comparison between hydrogel spacer and endorectal balloon: An analysis of intrafraction prostate motion during proton therapy.Journal of applied clinical medical physics · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe use of a tissue expander (hydrogel) for sparing of the rectum from increased irradiation during prostate radiotherapy is becoming popular. The goal of this study is to investigate the effect of a tissue expander (hydrogel) on the intrafraction prostate motion during radiotherapy. METHODS AND MATERIAL: Real time prostate motion was analysed for 26 patients and 742 fractions; 12 patients with and 14 patients without hydrogel (SpaceOAR™). The intra-fraction motion was quantified and compared between the two groups.
resultsThe average (±standard deviation) of the mean motion during the treatment for patients with and without hydrogel was 1.5 (±0.8 mm) and 1.1 (±0.9 mm) respectively (p < 0.05). The average time of motion >3 mm for patients with and without hydrogel was 7.7 % (±1.1 %) and 4.5 % (±0.9 %) respectively (p > 0.05). The hydrogel age, fraction number and treatment time were found to have no effect (R (2) < 0.05) on the prostate motion.
conclusionsDifferences in intrafraction motion in patients with hydrogel and without hydrogel were within measurement uncertainty (<1 mm). This result confirms that the addition of a spacer does not negate the need for intrafraction motion management if clinically indicated.
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