ArticleDevelopmental cognitive neuroscience2016
Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age.
Article in Developmental cognitive neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.Development and psychopathology · 2019Trial
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- The Critical Importance of Socioemotionally Related Functional Network Development During Infancy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Precision functional neuroimaging reveals individually specific auditory responses in infants.Developmental cognitive neuroscience · 2026Article
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants.bioRxiv : the preprint server for biology · 2025Article
- Infants' resting-state functional connectivity and event-related potentials: A multimodal approach to investigating the neural basis of infant novelty detection.Developmental psychology · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neonatal neural responses to novelty related to behavioral inhibition at 1 year.Developmental psychology · 2024Article
- Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Functional structure of local connections and differentiation of cerebral cortex areas in the neonate.NeuroImage · 2024Article
- Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Maternal prenatal social disadvantage and neonatal functional connectivity: Associations with psychopathology symptoms at age 12 months.Developmental psychology · 2024Article
- Intergenerational effects of racism on amygdala and hippocampus resting state functional connectivity.Scientific reports · 2024Article
- Brain morphometry and chronic inflammation in Bangladeshi children growing up in extreme poverty.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Associations between infant amygdala functional connectivity and social engagement following a stressor: A preliminary investigation.Developmental science · 2024Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
22 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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Abstract
The first year of life is an important period for emergence of fear in humans. While animal models have revealed developmental changes in amygdala circuitry accompanying emerging fear, human neural systems involved in early fear development remain poorly understood. To increase understanding of the neural foundations of human fear, it is important to consider parallel cognitive development, which may modulate associations between typical development of early fear and subsequent risk for fear-related psychopathology. We, therefore, examined amygdala functional connectivity with rs-fcMRI in 48 neonates (M=3.65 weeks, SD=1.72), and measured fear and cognitive development at 6-months-of-age. Stronger, positive neonatal amygdala connectivity to several regions, including bilateral anterior insula and ventral striatum, was prospectively associated with higher fear at 6-months. Stronger amygdala connectivity to ventral anterior cingulate/anterior medial prefrontal cortex predicted a specific phenotype of higher fear combined with more advanced cognitive development. Overall, findings demonstrate unique profiles of neonatal amygdala functional connectivity related to emerging fear and cognitive development, which may have implications for normative and pathological fear in later years. Consideration of infant fear in the context of cognitive development will likely contribute to a more nuanced understanding of fear, its neural bases, and its implications for future mental health.
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