ArticleThe Plant cell2015
Phosphorylation-Dependent Regulation of G-Protein Cycle during Nodule Formation in Soybean.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A Phytosulfokine signaling module activates the Nod factor receptor to control soybean nodulation.Nature communications · 2026Article
- The coupling effect ofSynthetic and systems biotechnology · 2026Article
- Heterotrimeric G-protein subunits regulate plant architecture, pod development, seed size, and symbiotic nodulation inaBIOTECH · 2025Article
- Review
- Nod factor perception: an integrative view of molecular communication during legume symbiosis.Plant molecular biology · 2022Review
- Interacting partners of Brassica juncea regulator of G-protein signaling protein suggest its role in cell wall metabolism and cellular signaling.Bioscience reports · 2022Article
- G-Protein Phosphorylation: Aspects of Binding Specificity and Function in the Plant Kingdom.International journal of molecular sciences · 2022Review
- Progress in soybean functional genomics over the past decade.Plant biotechnology journal · 2022Review
- Calcium/calmodulin-mediated microbial symbiotic interactions in plants.Frontiers in plant science · 2022Review
- Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits.International journal of molecular sciences · 2021Review
- Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants.International journal of molecular sciences · 2021Review
- A network-based comparative framework to study conservation and divergence of proteomes in plant phylogenies.Nucleic acids research · 2021Article
- The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation inFrontiers in plant science · 2021Article
- Heterotrimeric G-Protein Interactions Are Conserved Despite Regulatory Element Loss in Some Plants.Plant physiology · 2020Article
- Genome-wide survey of soybean papain-like cysteine proteases and their expression analysis in root nodule symbiosis.BMC plant biology · 2020Article
- Arabidopsis Transmembrane Receptor-Like Kinases (RLKs): A Bridge between Extracellular Signal and Intracellular Regulatory Machinery.International journal of molecular sciences · 2020Review
- Plant receptor-like kinase signaling through heterotrimeric G-proteins.Journal of experimental botany · 2020Review
- G protein α subunit suppresses sporangium formation through a serine/threonine protein kinase in Phytophthora sojae.PLoS pathogens · 2020Article
- Nucleotide exchange-dependent and nucleotide exchange-independent functions of plant heterotrimeric GTP-binding proteins.Science signaling · 2019Article
- Early signalling mechanisms underlying receptor kinase-mediated immunity in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
Corrections and comments
- Erratum issuedCORRECTION.2019
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signaling pathways mediated by heterotrimeric G-protein complexes comprising Gα, Gβ, and Gγ subunits and their regulatory RGS (Regulator of G-protein Signaling) protein are conserved in all eukaryotes. We have shown that the specific Gβ and Gγ proteins of a soybean (Glycine max) heterotrimeric G-protein complex are involved in regulation of nodulation. We now demonstrate the role of Nod factor receptor 1 (NFR1)-mediated phosphorylation in regulation of the G-protein cycle during nodulation in soybean. We also show that during nodulation, the G-protein cycle is regulated by the activity of RGS proteins. Lower or higher expression of RGS proteins results in fewer or more nodules, respectively. NFR1 interacts with RGS proteins and phosphorylates them. Analysis of phosphorylated RGS protein identifies specific amino acids that, when phosphorylated, result in significantly higher GTPase accelerating activity. These data point to phosphorylation-based regulation of G-protein signaling during nodule development. We propose that active NFR1 receptors phosphorylate and activate RGS proteins, which help maintain the Gα proteins in their inactive, trimeric conformation, resulting in successful nodule development. Alternatively, RGS proteins might also have a direct role in regulating nodulation because overexpression of their phospho-mimic version leads to partial restoration of nodule formation in nod49 mutants.
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