Evidence map›Paper›PMID 26498880›Full record

ReviewBrain research2016

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia.

Sarah D Ackerman, Kelly R Monk

Abstract readReview
In one paragraph

Review in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Ezh2 Loss-of-Function Alters Zebrafish Cerebellum Development.International journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Homemade: building the structure of the neurogenic niche.Frontiers in cell and developmental biology · 2023
    Review
  13. Lysophosphatidic acid signaling via LPAJournal of neurochemistry · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah D AckermanDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. Electronic address: sarah.degenova@wustl.edu.
Kelly R MonkDepartment of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. Electronic address: monkk@wustl.edu.

Funding

MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.R01NS079445 · NINDS · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2012 to 2020
$3.1M
Chemical and genetic screens for modulators of nervous system development and myelinationR01HD080601 · NICHD · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2014 to 2018
$1.6M
Gpr56 is a regulator of glial cell development and myelinationF31NS087801 · NINDS · WASHINGTON UNIVERSITY · PI ACKERMAN, SARAH D · 2014 to 2016
$68k
NICHD NIH HHS R01 HD080601NINDS NIH HHS F31 NS087801NINDS NIH HHS R01 NS079445
6 · The paper itself

Abstract

Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination. This article is part of a Special Issue entitled SI: Myelin Evolution.

Indexed as

AnimalsBiological EvolutionHumansMiceMyelin SheathNerve RegenerationZebrafishMouseMyelinOligodendrocyteSchwann cellZebrafish

Identifiers

PMID26498880
PMCPMC4838556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.