ArticleCerebral cortex (New York, N.Y. : 1991)2017
Community Socioeconomic Disadvantage in Midlife Relates to Cortical Morphology via Neuroendocrine and Cardiometabolic Pathways.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Neural correlates of socioeconomic status in early childhood: a systematic review of the literature.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Pooled it
- Sociodemographic disparities in corticolimbic structures.PloS one · 2019Trial
- Socioeconomic status, prefrontal cortical volume, and cardiometabolic risk in early adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Uncovering mediational pathways behind racial and socioeconomic disparities in brain volumes: insights from the UK Biobank study.GeroScience · 2025Article
- Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936.Molecular psychiatry · 2024Article
- Neurodevelopmental imprints of sociomarkers in adolescent brain connectomes.Scientific reports · 2024Article
- Pathways explaining racial/ethnic and socio-economic disparities in brain white matter integrity outcomes in the UK Biobank study.SSM - population health · 2024Article
- Deriving life-course residential histories in brain bank cohorts: A feasibility study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Relative brain age is associated with socioeconomic status and anxiety/depression problems in youth.Developmental psychology · 2024Article
- Racial and ethnic differences in the relationship between financial worry and white matter hyperintensities in Latinx, non-Latinx Black, and non-Latinx White older adults.Neurobiology of aging · 2023Article
- Support-Giving Is Associated With Lower Systemic Inflammation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- Association of Income with Post-Stroke Cognition and the Underlying Neuroanatomical Mechanism.Brain sciences · 2023Article
- A Social Gradient of Cortical Thickness in Adolescence: Relationships With Neighborhood Socioeconomic Disadvantage, Family Socioeconomic Status, and Depressive Symptoms.Biological psychiatry global open science · 2022Article
- Article
- Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Earth Dreams: Reimagining ARPA for Health of People, Places and Planet.International journal of environmental research and public health · 2021Article
- Long-term prognosis and educational determinants of brain network decline in older adult individuals.Nature aging · 2021Article
- Dissecting the midlife crisis: disentangling social, personality and demographic determinants in social brain anatomy.Communications biology · 2021Article
- Environmental influences on the pace of brain development.Nature reviews. Neuroscience · 2021Review
- Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.Neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Residing in communities of socioeconomic disadvantage confers risk for chronic diseases and cognitive aging, as well as risk for biological factors that negatively affect brain morphology. The present study tested whether community disadvantage negatively associates with brain morphology via 2 biological factors encompassing cardiometabolic disease risk and neuroendocrine function. Participants were 448 midlife adults aged 30-54 years (236 women) who underwent structural neuroimaging to assess cortical and subcortical brain tissue morphology. Community disadvantage was indexed by US Census data geocoded to participants' residential addresses. Cardiometabolic risk was indexed by measurements of adiposity, blood pressure, glucose, insulin, and lipids. Neuroendocrine function was indexed from salivary cortisol measurements taken over 3 days, from which we computed the cortisol awakening response, area-under-the-curve, and diurnal cortisol decline. Community disadvantage was associated with reduced cortical tissue volume, cortical surface area, and cortical thickness, but not subcortical morphology. Moreover, increased cardiometabolic risk and a flatter (dysregulated) diurnal cortisol decline mediated the associations of community disadvantage and cortical gray matter volume. These effects were independent of age, sex, and individual-level socioeconomic position. The adverse risks of residing in a disadvantaged community may extend to the cerebral cortex via cardiometabolic and neuroendocrine pathways.
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Registered trials
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