Evidence map›Paper›PMID 26498654›Full record

ArticleThe international journal of cardiovascular imaging2016

Left atrial minimum volume is more strongly associated with N-terminal pro-B-type natriuretic peptide than the left atrial maximum volume in a community-based sample.

Pär Hedberg, Jonas Selmeryd, Jerzy Leppert, Egil Henriksen

Abstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  11. Left atrial volume as risk marker: is minimum volume superior to maximum volume?European heart journal. Cardiovascular Imaging · 2024
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  12. Article
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  18. Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2020
    Article
  19. Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pär HedbergDepartment of Clinical Physiology, Västmanland County Hospital, 721 89, Västerås, Sweden. par.o.hedberg@ltv.se.ORCID http://orcid.org/0000-0001-5731-966X
Jonas SelmerydDepartment of Clinical Physiology, Västmanland County Hospital, 721 89, Västerås, Sweden.
Jerzy LeppertCentre for Clinical Research, Västmanland County Hospital, Uppsala University, Västerås, Sweden.
Egil HenriksenDepartment of Clinical Physiology, Västmanland County Hospital, 721 89, Västerås, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous data have demonstrated that left atrial (LA) minimum volume indexed for body surface area (LAVImin) is more strongly associated with the Doppler echocardiographic E/e' ratio than LA maximum volume index (LAVImax). We sought to explore if LAVImin was more closely related to serum levels of NT-proBNP than LAVImax and E/e' in the community. A community-based sample of 730 subjects underwent echocardiographic examinations and NT-proBNP measurements. The mean age of the participants was 66.3 years (range 38-86) and 72% were men. Age (Spearman correlation [rho] 0.533), LAVImin (rho 0.460), LAVImax (rho 0.360), estimated glomerular filtration rate (rho -0.349), and E/e' (rho 0.301; all P < 0.001) were strongly correlated with log-NT-proBNP. In a multiple linear regression model with log-NT-proBNP as dependent variable and LAVImin, LAVImax, E/e' ratio, and potential confounders as predictors, an adjusted R(2) of 44.9% was obtained. When excluding either of LAVImin (R(2) 42.6%, P < 0.001) or E/e' (R(2) 44.6%, P = 0.019) the model fit was significantly reduced. In contrast, when LAVImax was excluded the model fit was preserved (R(2) 45.0%, P = 0.69). To detect an NT-proBNP level of >125 ng/L, LAVImin yielded a significantly larger area under the receiver operating characteristic curve (AUC) of 0.749 than LAVImax (AUC 0.701; P < 0.001) and E/e' (AUC 0.661; P < 0.001). In our community-based sample, LAVImin was more strongly associated with NT-proBNP than LAVImax. Moreover, the discriminatory power to detect an elevated NT-proBNP level was stronger in LAVImin than in LAVImax and E/e'. Our findings support previous data that LAVImin may be more closely related to LV filling function than LAVImax.

Indexed as

Atrial Function, LeftAdultAgedAged, 80 and overArea Under CurveBiomarkersEchocardiography, DopplerFemaleHeart AtriaHeart DiseasesHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Doppler echocardiographyGeneral populationLeft atrial volumesNT-proBNP

Identifiers

PMID26498654
PMCPMC4751167

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.