Trial reportNeurorehabilitation and neural repair2016
The Effects of Stroke Type, Locus, and Extent on Long-Term Outcome of Gait Rehabilitation: The LEAPS Experience.
Trial report in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Soluble TREM2 ameliorates pathological phenotypes in ischemic stroke models via modulating neuronal and microglial functions.Experimental brain research · 2025Article
- Neuroimaging markers of dual impairment in cognition and physical performance following stroke: The Nor-COAST study.Frontiers in aging neuroscience · 2022Article
- Neural correlates of walking post-stroke: neuroimaging insights from the past decade.Experimental brain research · 2021Review
- Multidisciplinary Care after Acute Care for Stroke: A Prospective Comparison between a Multidisciplinary Post-Acute Care Group and a Standard Group Matched by Propensity Score.International journal of environmental research and public health · 2021Article
- Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type.Translational stroke research · 2021Article
- Article
- Sensor-based categorization of upper limb performance in daily life of persons with and without neurological upper limb deficits.Frontiers in rehabilitation sciences · 2021Article
- Stroke Lesion Impact on Lower Limb Function.Frontiers in human neuroscience · 2021Article
- Environmental enrichment during the chronic phase after experimental stroke promotes functional recovery without synergistic effects of EphA4 targeted therapy.Human molecular genetics · 2020Article
- Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Observational
- Reduced Upper Limb Recovery in Subcortical Stroke Patients With Small Prior Radiographic Stroke.Frontiers in neurology · 2019Article
- Gait Rehabilitation Using Functional Electrical Stimulation Induces Changes in Ankle Muscle Coordination in Stroke Survivors: A Preliminary Study.Frontiers in neurology · 2018Article
- Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models.Neurorehabilitation and neural repair · 2017Article
- Ventilatory threshold may be a more specific measure of aerobic capacity than peak oxygen consumption rate in persons with stroke.Topics in stroke rehabilitation · 2017Article
- Perceptions of physical activity and walking in an early stage after stroke or acquired brain injury.PloS one · 2017Article
- Understanding the Mechanisms of Recovery and/or Compensation following Injury.Neural plasticity · 2017Review
- Recovery and Rehabilitation after Intracerebral Hemorrhage.Seminars in neurology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Background Paresis in stroke is largely a result of damage to descending corticospinal and corticobulbar pathways. Recovery of paresis predominantly reflects the impact on the neural consequences of this white matter lesion by reactive neuroplasticity (mechanisms involved in spontaneous recovery) and experience-dependent neuroplasticity, driven by therapy and daily experience. However, both theoretical considerations and empirical data suggest that type of stroke (large vessel distribution/lacunar infarction, hemorrhage), locus and extent of infarction (basal ganglia, right-hemisphere cerebral cortex), and the presence of leukoaraiosis or prior stroke might influence long-term recovery of walking ability. In this secondary analysis based on the 408 participants in the Locomotor Experience Applied Post-Stroke (LEAPS) study database, we seek to address these possibilities. Methods Lesion type, locus, and extent were characterized by the 2 neurologists in the LEAPS trial on the basis of clinical computed tomography and magnetic resonance imaging scans. A series of regression models was used to test our hypotheses regarding the effects of lesion type, locus, extent, and laterality on 2- to 12-month change in gait speed, controlling for baseline gait speed, age, and Berg Balance Scale score. Results Gait speed change at 1 year was significantly reduced in participants with basal ganglia involvement and prior stroke. There was a trend toward reduction of gait speed change in participants with lacunar infarctions. The presence of right-hemisphere cortical involvement had no significant impact on outcome. Conclusions Type, locus, and extent of lesion, and the loss of substrate for neuroplastic effect as a result of prior stroke may affect long-term outcome of rehabilitation of hemiparetic gait.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.