ArticleNature communications2015
An orphan gene is necessary for preaxial digit formation during salamander limb development.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Development of a ZRS Reporter System for the Newt (Biomedicines · 2024Article
- Orphan geneHorticulture research · 2024Article
- Role of Brassica orphan gene BrLFM on leafy head formation in Chinese cabbage (Brassica rapa).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The Lost and Found: Unraveling the Functions of Orphan Genes.Journal of developmental biology · 2023Review
- Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- The latent dedifferentiation capacity of newt limb muscles is unleashed by a combination of metamorphosis and body growth.Scientific reports · 2022Article
- Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.Cold Spring Harbor perspectives in biology · 2022Review
- Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration.Frontiers in cell and developmental biology · 2022Article
- Research Advances and Prospects of Orphan Genes in Plants.Frontiers in plant science · 2022Review
- Reviewing the Effects of Skin Manipulations on Adult Newt Limb Regeneration: Implications for the Subcutaneous Origin of Axial Pattern Formation.Biomedicines · 2021Article
- Towards comparative analyses of salamander limb regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- From Autonomy to Integration, From Integration to Dynamically Balanced Integrated Co-existence: Non-aging as the Third Stage of Development.Frontiers in aging · 2021Article
- Brassica rapa orphan genes largely affect soluble sugar metabolism.Horticulture research · 2020Article
- Article
- Regeneration enhancers: A clue to reactivation of developmental genes.Development, growth & differentiation · 2020Review
- Mitochondrial Fostering: The Mitochondrial Genome May Play a Role in Plant Orphan Gene Evolution.Frontiers in plant science · 2020Article
- Article
- Comparative transcriptomics of limb regeneration: Identification of conserved expression changes among three species of Ambystoma.Genomics · 2019Article
- A wheat NAC interacts with an orphan protein and enhances resistance to Fusarium head blight disease.Plant biotechnology journal · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Limb development in salamanders differs from other tetrapods in that the first digits to form are the two most anterior (preaxial dominance). This has been proposed as a salamander novelty and its mechanistic basis is unknown. Salamanders are the only adult tetrapods able to regenerate the limb, and the contribution of preaxial dominance to limb regeneration is unclear. Here we show that during early outgrowth of the limb bud, a small cohort of cells express the orphan gene Prod1 together with Bmp2, a critical player in digit condensation in amniotes. Disruption of Prod1 with a gene-editing nuclease abrogates these cells, and blocks formation of the radius and ulna, and outgrowth of the anterior digits. Preaxial dominance is a notable feature of limb regeneration in the larval newt, but this changes abruptly after metamorphosis so that the formation of anterior and posterior digits occurs together within the autopodium resembling an amniote-like pattern.
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