ArticleThe Journal of physiology2016
Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
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- Article
- Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress.IBRO neuroscience reports · 2021Article
- Effects of anesthetic agents on inflammation in Caco-2, HK-2 and HepG2 cells.Experimental and therapeutic medicine · 2021Article
- Transfer of oral bacteria to the fetus during late gestation.Scientific reports · 2021Article
- Large animal models for translational research in acute kidney injury.Renal failure · 2020Review
- Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells.Clinics (Sao Paulo, Brazil) · 2020Article
- Transcriptomic evidence that cortisol alters perinatal epicardial adipose tissue maturation.American journal of physiology. Endocrinology and metabolism · 2019Article
- Current paradigms and new perspectives on fetal hypoxia: implications for fetal brain development in late gestation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery.Animal frontiers : the review magazine of animal agriculture · 2019Article
- Proof of principle: Physiological transfer of small numbers of bacteria from mother to fetus in late-gestation pregnant sheep.PloS one · 2019Article
- Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex.The Journal of physiology · 2018Article
- Ketamine Reduces Inflammation Pathways in the Hypothalamus and Hippocampus Following Transient Hypoxia in the Late-Gestation Fetal Sheep.Frontiers in physiology · 2018Article
- ERK and p38 Upregulation versus Bcl-6 Downregulation in Rat Kidney Epithelial Cells Exposed to Prolonged Hypoxia.Cell transplantation · 2017Article
- Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.Scientific reports · 2017Article
- RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets.Endocrinology · 2017Article
- Ketamine modulates fetal hemodynamic and endocrine responses to umbilical cord occlusion.Physiological reports · 2016Article
- Hypoxia, fetal and neonatal physiology: 100 years on from Sir Joseph Barcroft.The Journal of physiology · 2016Article
- Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex.Physiological reports · 2016Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Acute fetal hypoxia is a form of fetal stress that stimulates renal vasoconstriction and ischaemia as a consequence of the physiological redistribution of combined ventricular output. Because of the potential ischaemia-reperfusion injury to the kidney, we hypothesized that it would respond to hypoxia with an increase in the expression of inflammatory genes, and that ketamine (an N-methyl-D-aspartate receptor antagonist) would reduce or block this response. Hypoxia was induced for 30 min in chronically catheterized fetal sheep (125 ± 3 days), with or without ketamine (3 mg kg(-1)) administered intravenously to the fetus 10 min prior to hypoxia. Gene expression in fetal kidney cortex collected 24 h after the onset of hypoxia was analysed using ovine Agilent 15.5k array and validated with qPCR and immunohistochemistry in four groups of ewes: normoxic control, normoxia + ketamine, hypoxic control and hypoxia + ketamine (n = 3-4 per group). Significant differences in gene expression between groups were determined with t-statistics using the limma package for R (P ≤ 0.05). Enriched biological processes for the 427 upregulated genes were immune and inflammatory responses and for the 946 downregulated genes were metabolic processes. Ketamine countered the effects of hypoxia on upregulated immune/inflammatory responses as well as the downregulated metabolic responses. We conclude that our transcriptomics modelling predicts that hypoxia activates inflammatory pathways and reduces metabolism in the fetal kidney cortex, and ketamine blocks or ameliorates this response. The results suggest that ketamine may have therapeutic potential for protection from ischaemic renal damage.
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