ArticleScientific reports2015
Disruption of diapause induction by TALEN-based gene mutagenesis in relation to a unique neuropeptide signaling pathway in Bombyx.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 71 citations in OpenAlex.
- Temporal Dynamics of Extracellular Signal-Regulated Kinase Phosphorylation and Associated Signaling Genes During Embryonic Development in Bombyx mori.Archives of insect biochemistry and physiology · 2026Article
- Evidence for the Link Between KK-42 and theBiology · 2026Article
- Egg Microinjection for the SilkwormBio-protocol · 2025Article
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- Circadian Clock Genes Regulate Temperature-Dependent Diapause Induction in SilkwormFrontiers in physiology · 2022Article
- Expressions of the Protein Phosphatases PP1 and PP4 during the Embryonic Diapause Process of the SilkwormZoological studies · 2022Article
- Circadian Clock GeneBiology · 2021Article
- Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms.Scientific reports · 2021Article
- Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkwormProceedings of the National Academy of Sciences of the United States of America · 2021Article
- An insulin-like growth factor-like peptide promotes ovarian development in the silkmoth Bombyx mori.Scientific reports · 2019Article
- Effects of transgenic overexpression of diapause hormone and diapause hormone receptor genes on non-diapause silkworm.Transgenic research · 2017Article
- Identification of functional enolase genes of the silkworm Bombyx mori from public databases with a combination of dry and wet bench processes.BMC genomics · 2017Article
- Highly efficient and inducible DNA excision in transgenic silkworms using the FLP/FRT site-specific recombination system.Transgenic research · 2016Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insect neuropeptide family FXPRLa, which carries the Phe-Xaa-Pro-Arg-Leu-NH2 sequence at the C-terminus, is involved in many physiological processes. Although ligand-receptor interactions in FXPRLa signaling have been examined using in vitro assays, the correlation between these interactions and in vivo physiological function is unclear. Diapause in the silkworm, Bombyx mori, is thought to be elicited by diapause hormone (DH, an FXPRLa) signaling, which consists of interactions between DH and DH receptor (DHR). Here, we performed transcription activator-like effector nuclease (TALEN)-based mutagenesis of the Bombyx DH-PBAN and DHR genes and isolated the null mutants of these genes in a bivoltine strain. All mutant silkworms were fully viable and showed no abnormalities in the developmental timing of ecdysis or metamorphosis. However, female adults oviposited non-diapause eggs despite diapause-inducing temperature and photoperiod conditions. Therefore, we conclude that DH signaling is essential for diapause induction and consists of highly sensitive and specific interactions between DH and DHR selected during ligand-receptor coevolution in Bombyx mori.
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