Evidence map›Paper›PMID 26497857›Full record

Trial reportAmino acids2016

Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development.

Julie A Mennella, Jillian C Trabulsi, Mia A Papas

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Amino acids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00994747 (Sensitive Periods in Early Flavor Learning), which is not on this map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00994747 nacompletednot on this map

Sensitive Periods in Early Flavor Learning

TypeinterventionalSponsorMonell Chemical Senses CenterRan2006 to 2010Enrolled79ConditionsHealthyArmsNutramigen (Flavor and Type of Infant Formula), Enfamil, milk-based formula
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Nutrition in the First 1000 Days: Ten Practices to Minimize Obesity Emerging from Published Science.International journal of environmental research and public health · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Julie A MennellaMonell Chemical Senses Center, 3500 Market Street, Philadelphia, PA, 19104-3308, USA. mennella@monell.org.
Jillian C TrabulsiDepartment of Behavioral Health and Nutrition, University of Delaware, 015 Carpenter Sports Building, 26 North College Avenue, Newark, DE, 19716, USA.
Mia A PapasDepartment of Behavioral Health and Nutrition, University of Delaware, 015 Carpenter Sports Building, 26 North College Avenue, Newark, DE, 19716, USA.
University of Delaware · USMonell Chemical Senses Center · US

Funding

MODEL FOR SENSITIVE PERIODS IN EARLY FLAVOR LEARNINGR01HD037119 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE · 1999 to 2016
$3.9M
Impact of diet composition during infancy on energy balance, satiety and growthR01HD072307 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2012 to 2016
$2.7M
NICHD NIH HHS R01 HD037119NICHD NIH HHS R01 HD072307NICHD NIH HHS R01HD072307NICHD NIH HHS R01HD37119
6 · The paper itself

Abstract

unlabelledLittle research has focused on infant developmental effects, other than growth, of formulas that differ substantially in the form of protein. To examine development of infants fed formulas differing in free amino acid content, we randomized 0.5-month-old infants (n = 79) to either a control group who fed only cow milk formula (CMF) during the first 8 months (CMF8), or to one of two experimental groups: one experimental group fed extensively protein hydrolyzed formula (EHF) for 1-3 months during first 4.5 months (EHF1-3) of life, and the other fed EHF for 8 months (EHF8). The Mullen Scales of Early Learning were administered monthly from 1.5 to 8.5 months to assess fine (FM) and gross (GM) motor control, receptive (RL) and expressive (EL) language, visual reception (VR), and an early learning composite (ELC). Across the 5.5-8.5-month time period, when compared to CMF8 infants, GM scores in EHF1-3 infants averaged 1.5 points higher (95 % CI 0.1, 3.0) and in EHF8 infants 2.2 points higher (95 % CI 0.3, 4.0). Similarly, VR scores averaged 1.9 points higher (95 % CI 0.1, 3.8) in EHF1-3 infants and 2.2 points higher (95 % CI -0.2, 4.5) in EHF8 infants. EHF8 infants' RL scores averaged 1.8 points lower (95 % CI 0.1, 3.6) than CMF8 infants. These data suggest that the form of protein in infant formula may impact cognitive development and that the higher free amino acid content in breast milk may be a contributing factor to the differential cognitive development between breastfed and CMF-fed infants. CLINICAL

trial registrationclinicaltrials.gov NCT00994747.

Indexed as

Child DevelopmentCognitionAmino AcidsAnimalsCattleFemaleHumansInfantInfant FormulaInfant, NewbornInfant Nutritional Physiological PhenomenaLearningMaleMilkProtein HydrolysatesAmino AcidsProtein HydrolysatesCognitive developmentCow milk formulaExtensive protein hydrolysate formulaFree amino acids

Identifiers

PMID26497857
PMCPMC4754137
OpenAlexW1501894996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.