Evidence map›Paper›PMID 26497607›Full record

ArticleOsteoarthritis and cartilage2016

Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative.

G B Joseph, J F Hilton, P M Jungmann, J A Lynch, N E Lane, F Liu, C E McCulloch, I Tolstykh, T M Link, M C Nevitt

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Effects of TJournal of magnetic resonance imaging : JMRI · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

G B JosephMusculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA.
J F HiltonDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA.
P M JungmannDepartment of Radiology, Technische Universitaet Muenchen, Ismaninger Strasse 22, 81675 Munich, Germany.
J A LynchDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA.
N E LaneDepartment of Internal Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA.
F LiuDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA.
C E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA.
I TolstykhDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA.
T M LinkMusculoskeletal and Quantitative Imaging Research, Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107, USA.
M C NevittDepartment of Epidemiology and Biostatistics, University of California San Francisco, Mission Hall, 550 16th St. 2nd Floor, Campus Box #0560 San Francisco, CA 94158, USA. Electronic address: mnevitt@psg.ucsf.edu.
University of California, San Francisco · USUniversity of California Davis Medical Center · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
–
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
NCATS NIH HHS UL1 TR001070NHLBI NIH HHS HHSN268201000019CNIAMS NIH HHS N01 AR022258NIAMS NIH HHS N01 AR022259NIAMS NIH HHS N01 AR022260NIAMS NIH HHS N01 AR022261NIAMS NIH HHS N01 AR022262NIAMS NIH HHS N01-AR-2-2258NIAMS NIH HHS N01-AR-2-2259NIAMS NIH HHS N01-AR-2-2260NIAMS NIH HHS N01-AR-2-2261NIAMS NIH HHS N01-AR-2-2262NIAMS NIH HHS P30 AR066262
6 · The paper itself

Abstract

purposeTo determine if asymmetry between hips in pain or radiographic osteoarthritis (RHOA) is associated with worse pain and joint space narrowing (JSN) at baseline and longitudinally in knees contralateral to more affected hips.

methodsWe studied 279 participants in the Osteoarthritis Initiative with baseline asymmetry between hips in pain and 483 with asymmetry in RHOA none of whom had a hip replacement for ≥4 years after baseline. RHOA assessed from pelvis radiographs was categorized as none, possible or definite and hip pain on most days of a month in the past year as present/absent. Knee pain (WOMAC scale) and JSN (fixed flexion radiographs) were categorized as none, mild and moderate-severe. We compared knees contralateral and ipsilateral to more affected hips on baseline knee pain and JSN using clustered multinomial regression and on change in knee pain and JSN over 4-5 years using generalized linear and logistic estimating equations.

resultsKnees contralateral to painful hips had less baseline pain ("moderate-severe" vs "none", relative risk ratio [RRR]: 0.39, 95% CI = 0.27-0.57), but greater baseline JSN ("moderate-severe" vs "none", RRR: 1.62, 95% CI = 1.09-2.38) and greater worsening of pain during follow-up (P = 0.001). Knees contralateral to hips with worse RHOA had nonsignificant trends for greater baseline JSN (P = 0.10) and JSN progression (P = 0.17).

conclusionThese findings provide limited support for the hypothesis that early asymmetry in hip pain and RHOA is associated with worse pain and structural outcomes in knees contralateral to the more affected hip.

Indexed as

AgedDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedOsteoarthritis, HipOsteoarthritis, KneePainPain MeasurementRadiographyHip osteoarthritisJoint painKnee osteoarthritisStructural outcomes

Identifiers

PMID26497607
PMCPMC4761312
OpenAlexW1830756524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.