ArticleBMC cardiovascular disorders2015
The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.
Article in BMC cardiovascular disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A systematic review and bioinformatic study on clinical, paraclinical, and genetic factors predisposing to stent restenosis following percutaneous coronary intervention.BMC cardiovascular disorders · 2024Pooled it
- Genetic insights into 5-LOX-activating protein: a narrative review of disease associations.Human genomics · 2025Review
- Single Nucleotide Polymorphisms' Causal Structure Robustness within Coronary Artery Disease Patients.Biology · 2023Article
- Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia.Caspian journal of internal medicine · 2023Article
- Diabetes and restenosis.Cardiovascular diabetology · 2022Review
- The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate.Journal of medical virology · 2021Article
- Transcriptomics of Human Arteriovenous Fistula Failure: Genes Associated With Nonmaturation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Article
- Biochemical Analysis and Association of Butyrylcholinesterase SNPs rs3495 and rs1803274 with Substance Abuse Disorder.Journal of molecular neuroscience : MN · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to identify gene polymorphisms that confer susceptibility to in-stent restenosis after coronary artery bare-metal stenting in a Central European population.
methods160 controls without post-percutaneous coronary intervention in-stent restenosis were matched for age, sex, vessel diameter, and diabetes to 160 consecutive cases involving in-stent restenosis of the target lesion within 12 months. Using real time polymerase chain reaction and melting-curve analysis, we detected 13 single-nucleotide polymorphisms in 11 candidate genes - rs1803274 (BCHE gene), rs529038 (ROS1), rs1050450 (GPX1), rs1800849 (UCP3), rs17216473 (ALOX5AP), rs7412, rs429358 (ApoE), rs2228570 (VDR), rs7041, rs4588 (GC), rs1799986 (LRP1) and rs2228671 (LDLR). Multivariable logistic regression was used to test for associations.
resultsThe rs1803274 polymorphism of BCHE was significantly associated with in-stent restenosis (OR 1.934; 95 % CI: 1.181-3.166; p = 0.009). No association was found with the other studied SNPs.
conclusionsThe A allele of rs1803274 represents a risk factor for in-stent restenosis in Central European patients after percutaneous coronary intervention with bare-metal stent implantation.
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