ArticleBMC infectious diseases2015
Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Disease Burden of RSV Infections and Bronchiolitis in Young Children (< 5 Years) in Primary Care and Emergency Departments: A Systematic Literature Review.Influenza and other respiratory viruses · 2024Pooled it
- Cost of childhood RSV management and cost-effectiveness of RSV interventions: a systematic review from a low- and middle-income country perspective.BMC medicine · 2023Pooled it
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- Trial
- Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Trial
- Cost of respiratory syncytial virus hospitalisation in Brazilian infants: a micro-costing study from the perspective of a Brazilian tertiary public hospital, 2020-2023.BMC public health · 2025Article
- Article
- Assessing the long-term economic impact of wheezing episodes after severe RSV disease in children from Argentina: a cost of illness analysis.BMJ public health · 2024Article
- Cost of illness due to respiratory syncytial virus acute lower respiratory tract infection among infants hospitalized in Argentina.BMC public health · 2024Article
- Etiology of Acute Lower Respiratory Illness Hospitalizations Among Infants in 4 Countries.Open forum infectious diseases · 2023Article
- Incidence of respiratory virus illness and hospitalizations in a Panama and El Salvador birth cohort, 2014-2018.Lancet regional health. Americas · 2022Article
- Diagnostic Stewardship-The Impact of Rapid Diagnostic Testing for Paediatric Respiratory Presentations in the Emergency Setting: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Article
- Circulation of human coronaviruses OC43 and 229E in Córdoba, Argentina.Archives of virology · 2021Observational
- Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study.The Lancet. Child & adolescent health · 2019Article
- Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses, 2010-2015.The Journal of infection · 2019Article
- Estimation of influenza and respiratory syncytial virus hospitalizations using sentinel surveillance data-La Paz, Bolivia. 2012-2017.Influenza and other respiratory viruses · 2019Article
- Burden of influenza-associated respiratory hospitalizations in the Americas, 2010-2015.PloS one · 2019Article
- Timing of respiratory syncytial virus and influenza epidemic activity in five regions of Argentina, 2007-2016.Influenza and other respiratory viruses · 2019Article
- Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - Latin America, 2013.Vaccine · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries.
methodsDuring 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5 years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction.
resultsThe incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6 months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6-23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362-789).
conclusionsOur findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.
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