Evidence map›Paper›PMID 26497333›Full record

ArticleThe journal of physiological sciences : JPS2016

Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes.

Sevil Korkmaz-Icöz, Ayhan Atmanli, Tamás Radovits, Shiliang Li, Peter Hegedüs, Mihály Ruppert, Paige Brlecic, Yutaka Yoshikawa, Hiroyuki Yasui, Matthias Karck and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Zinc: a metallic shield against cardiac inflammation.Metallomics : integrated biometal science · 2026
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  8. Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Sevil Korkmaz-IcözDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany. korkmaz@uni-heidelberg.de.
Ayhan AtmanliDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Tamás RadovitsHeart and Vascular Center, Semmelweis University, 1122, Budapest, Hungary.
Shiliang LiDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Peter HegedüsDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Mihály RuppertDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Paige BrlecicDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Yutaka YoshikawaDepartment of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, 607-8414, Japan.
Hiroyuki YasuiDepartment of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, 607-8414, Japan.
Matthias KarckDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Gábor SzabóDepartment of Cardiac Surgery, University of Heidelberg, INF 326 (2. OG), 69120, Heidelberg, Germany.
Heidelberg University · DEKyoto Pharmaceutical University · JPSemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently demonstrated that the pre-treatment of rats with zinc and acetylsalicylic acid complex in the form of bis(aspirinato)zinc(II) [Zn(ASA)2] is superior to acetylsalicylic acid in protecting the heart from acute myocardial ischemia. Herein, we hypothesized that Zn(ASA)2 treatment after the onset of an acute myocardial injury could protect the heart. The rats were treated with a vehicle or Zn(ASA)2 after an isoproterenol injection. Isoproterenol-induced cardiac damage [inflammatory infiltration into myocardial tissue, DNA-strand breakage evidenced by TUNEL-assay, increased 11-dehydro thromboxane (TX)B2-levels, elevated ST-segment, widened QRS complex and prolonged QT-interval] was prevented by the Zn(ASA)2 treatment. In isoproterenol-treated rats, load-independent left ventricular contractility parameters were significantly improved after Zn(ASA)2. Furthermore, Zn(ASA)2 significantly increased the myocardial mRNA-expression of superoxide dismutase-1, glutathione peroxidase-4 and decreased the level of Na(+)/K(+)/ATPase. Postconditioning with Zn(ASA)2 protects the heart from acute myocardial ischemia. Its mechanisms of action might involve inhibition of pro-inflammatory prostanoids and upregulation of antioxidant enzymes.

Indexed as

AnimalsAntioxidantsAspirinGlutathione PeroxidaseHeart InjuriesHeart VentriclesMaleMyocardial InfarctionMyocardiumPhospholipid Hydroperoxide Glutathione PeroxidaseRatsRats, Sprague-DawleySodium-Potassium-Exchanging ATPaseSuperoxide DismutaseSuperoxide Dismutase-1Up-RegulationAntioxidantsAspirinGlutathione Peroxidaseglutathione peroxidase 4, ratPhospholipid Hydroperoxide Glutathione PeroxidaseSodium-Potassium-Exchanging ATPaseSuperoxide DismutaseSuperoxide Dismutase-1ZincIsoproterenolMyocardial ischemiaZinc complex of acetylsalicylic acid

Identifiers

PMID26497333
PMCPMC10717564
OpenAlexW2295048175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.