ArticleRheumatology international2017
Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival.
Article in Rheumatology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Arrhythmias and Conduction Disturbances in Patients with Systemic Sclerosis-A Systematic Literature Review.International journal of molecular sciences · 2022Pooled it
- Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature.Arthritis research & therapy · 2019Pooled it
- Identification of Risk Factors for Incident Left Ventricular Systolic Dysfunction and Predictors of Cardiac Recovery in Patients With Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Article
- First-line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING-SIR registry.European journal of clinical investigation · 2025Article
- Risk of ischaemic and non-ischaemic heart failure in patients with systemic sclerosis: a population-based study.Rheumatology (Oxford, England) · 2025Article
- Cardiac Involvement and Heart Failure Staging in Patients with Systemic Sclerosis Without Pulmonary Arterial Hypertension.Journal of clinical medicine · 2025Article
- Inflammatory Biomarkers and Lipid Parameters May Predict an Increased Risk for Atrial Arrhythmias in Patients with Systemic Sclerosis.Biomedicines · 2025Article
- Cardiac magnetic resonance in systemic sclerosis: imaging features and potential prognostic implications. A literature review.Frontiers in medicine · 2025Review
- Effect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study.Frontiers in endocrinology · 2025Article
- Multimodal Screening for Pulmonary Arterial Hypertension in Systemic Scleroderma: Current Methods and Future Directions.Medicina (Kaunas, Lithuania) · 2024Review
- Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis.RMD open · 2024Article
- Arrhythmia in patients with systemic sclerosis: incidence, risk factors and impact on mortality in a Swedish register-based study.RMD open · 2024Article
- Scleroderma myocarditis with severe secondary mitral regurgitation successfully treated with transcatheter edge-to-edge repair: a case report.European heart journal. Case reports · 2024Article
- A Rare Presentation of Systemic Sclerosis.Cureus · 2023Article
- Connective tissue disease-associated pulmonary hypertension: A comprehensive review.Pulmonary circulation · 2023Review
- Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample.BMC rheumatology · 2023Article
- Predictors and survival of cardiomyopathy determined by echocardiography in Thai patients with early systemic sclerosis: an inception cohort study.Scientific reports · 2023Article
- The clinical characteristics and outcomes of patients with systemic sclerosis with myocardial involvement.Orphanet journal of rare diseases · 2023Article
- Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
Corrections and comments
- Erratum issuedErratum to: Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival.2017 · Del Castillo, Alfredo Guillén [corrected to Guillén-Del Castillo, Alfredo]
Authors and funding
11 authors.
Funding
Abstract
Cardiac involvement (CI) is a known complication of SSc associated with increased mortality. Our objective was to describe a cohort of patients with SSc and CI and to assess the differences between cutaneous subsets regarding their presentation and survival. Three hundred and ninety-three Spanish patients from a single center, diagnosed with SSc, were retrospectively studied for evidence of CI using noninvasive and invasive tests from 1976 to 2011. Clinical, epidemiological, immunological and therapeutic features of patients with CI were compared to those without it and within the different cutaneous subsets of SSc. CI was present in 173 (44 %) patients. Mitral regurgitation (67 %), conduction alterations (45 %) and left ventricle diastolic dysfunction (40 %) were the most common findings. Pericardial involvement and heart failure were more frequent in diffuse SSc (dcSSc) than in limited or sine scleroderma SSc. CI accounted for 20 % of deaths, and it was an independent mortality risk factor (HR 2.1, P = 0.02), but once CI was established, classical dcSSc mortality risk factors determined mortality. Patients with dcSSc developed CI faster than limited (HR 1.9, P = 0.003) or sine SSc patients (HR 2.5, P = 0.002), specially during the first year after SSc onset. We found statistically significant differences between the 3 SSc subsets in the presentation of pericardial involvement and heart failure. CI increased the mortality and appeared at a higher rate, especially during the first year after SSc onset. Screening for heart involvement should be performed at diagnosis and during follow-up.
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