Evidence map›Paper›PMID 26497128›Full record

ArticleJournal of assisted reproduction and genetics2015

Lipidomics analysis of follicular fluid by ESI-MS reveals potential biomarkers for ovarian endometriosis.

Fernanda Bertuccez Cordeiro, Thais Regiani Cataldi, Kayla Jane Perkel, Lívia do Vale Teixeira da Costa, Raquel Cellin Rochetti, Juliana Stevanato, Marcos Nogueira Eberlin, Daniel Suslik Zylbersztejn, Agnaldo Pereira Cedenho, Edson Guimarães Lo Turco

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  10. Metabolomics for the identification of biomarkers in endometriosis.Archives of gynecology and obstetrics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fernanda Bertuccez CordeiroHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Thais Regiani CataldiHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Kayla Jane PerkelDepartment of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Lívia do Vale Teixeira da CostaHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Raquel Cellin RochettiHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Juliana StevanatoHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Marcos Nogueira EberlinInstitute of Chemistry, University of Campinas, Campinas, SP, Brazil.
Daniel Suslik ZylbersztejnHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil. danielsuslik@gmail.com.
Agnaldo Pereira CedenhoHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Edson Guimarães Lo TurcoHuman Reproduction Section, Division of Urology, Department of Surgery, Sao Paulo Federal University, R Embau, 231, São Paulo, SP, 04039-060, Brazil.
Universidade Federal de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the present study was to analyze the lipid profile of follicular fluid from patients with endometriosis and endometrioma who underwent in vitro fertilization treatment (IVF).

methodsThe control group (n = 10) was composed of women with tubal factor or minimal male factor infertility who had positive pregnancy outcomes after IVF. The endometriosis group consisted of women with endometriosis diagnosed by videolaparoscopy (n = 10), and from the same patients, the endometriomas fluids were collected, which composed the endometrioma group (n = 10). From the follicular fluid and endometriomas, lipids were extracted by the Bligh and Dyer method, and the samples were analyzed by tandem mass spectrometry.

resultsWe observed phosphatidylglycerol phosphate, phosphatidylcholine, phosphatidylserine, and phosphatidylnositol bisphosphate in the control group. In the endometriosis group, sphingolipids and phosphatidylcholines were more abundant, while in the endometrioma group, sphingolipids and phosphatidylcholines with different m/z from the endometriosis group were found in high abundance.

conclusionThis analysis demonstrated that there is a differential representation of these lipids according to their respective groups. In addition, the lipids found are involved in important mechanisms related to endometriosis progress in the ovary. Thus, the metabolomic approach for the study of lipids may be helpful in potential biomarker discovery.

Indexed as

Lipid MetabolismBiomarkersEndometriosisFemaleFollicular FluidHumansLipidsMetabolomicsSpectrometry, Mass, Electrospray IonizationBiomarkersLipidsEndometriomaEndometriosisFollicular fluidIVFMass spectrometry, lipidsMetabolomics

Identifiers

PMID26497128
PMCPMC4681741
OpenAlexW1829972343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.