ArticleHistopathology2016
Infiltrating epitheliosis of the breast: characterization of histological features, immunophenotype and genomic profile.
Article in Histopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer.Breast cancer research and treatment · 2018Trial
- A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report.BMC women's health · 2024Article
- Case report: Fibroadenomas associated with atypical ductal hyperplasia and infiltrating epitheliosis mimicking invasive carcinoma.Frontiers in oncology · 2024Article
- Genetic analysis of low-grade adenosquamous carcinoma of the breast progressing to high-grade metaplastic carcinoma.Breast cancer research and treatment · 2023Article
- Tall Cell Carcinoma with Reversed Polarity: Case Report of a Rare Special Type of Breast Cancer and Review of the Literature.Biomedicines · 2023Article
- Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges.Journal of imaging · 2022Review
- Tall cell carcinoma with reversed polarity: case report with gene sequencing and literature review.Gland surgery · 2021Article
- Article
- The Spectrum of Triple-Negative Breast Disease: High- and Low-Grade Lesions.The American journal of pathology · 2017Review
- Next generation sequencing of the nidus of early (adenosquamous proliferation rich) radial sclerosing lesions of the breast reveals evidence for a neoplastic precursor lesion.The journal of pathology. Clinical research · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
aimsInfiltrating epitheliosis is a rare complex sclerosing lesion (CSL) of the breast, characterized by infiltrating ducts immersed in a scleroelastotic stroma and filled with cells having architectural and cytological patterns reminiscent of those of usual ductal hyperplasia. In this study we sought to define the molecular characteristics of infiltrating epitheliosis. METHODS AND
resultsEight infiltrating epitheliosis, adjacent breast lesions (one usual ductal hyperplasia, one papilloma, one micropapillary ductal carcinoma in situ and one low-grade adenosquamous carcinoma), and corresponding normal breast tissue from each case were microdissected and subjected to massively parallel sequencing analysis targeting all coding regions of 254 genes mutated recurrently in breast cancer and/or related to DNA repair. Mutations in components of the PI3K pathway were found in all infiltrating epitheliosis samples, seven of which harboured PIK3CA hotspot mutations, while the remaining case displayed a PIK3R1 somatic mutation.
conclusionsSomatic mutations affecting PI3K pathway genes were found to be highly prevalent in infiltrating epitheliosis, suggesting that these lesions may be neoplastic rather than hyperplastic. The landscape of somatic genetic alterations found in infiltrating epitheliosis is similar to that of radial scars/CSLs, suggesting that infiltrating epitheliosis may represent one end of this spectrum of lesions.
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