ArticleScientific reports2015
Detection and characterization of mineralo-organic nanoparticles in human kidneys.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026Review
- Calcifying nanoparticles induce apoptosis and calcification in bone marrow mesenchymal stem cellsWorld journal of stem cells · 2025Article
- Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications.BMC urology · 2025Review
- Mechanism of influence of calcified nanoparticles in the development of calcified diseases (Review).Biomedical reports · 2025Review
- Mineralo-organic particles inhibit influenza A virus infection by targeting viral hemagglutinin activity.Nanomedicine (London, England) · 2024Article
- Nanocrystal-induced chronic tubular-nephropathy in tropical countries: diagnosis, mitigation, and eradication.European journal of medical research · 2023Article
- Association between aortic calcification and the presence of kidney stones: calcium oxalate calculi in focus.International urology and nephrology · 2022Article
- Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation-Induced Cardiovascular Consequences in Early Metabolic Impairment.Journal of the American Heart Association · 2021Article
- Tetracycline attenuates calcifying nanoparticles-induced renal epithelial injury through suppression of inflammation, oxidative stress, and apoptosis in rat models.Translational andrology and urology · 2019Article
- A Brief Review about the Role of Nanomaterials, Mineral-Organic Nanoparticles, and Extra-Bone Calcification in Promoting Carcinogenesis and Tumor Progression.Biomedicines · 2019Review
- Calcifying nanoparticles induce cytotoxicity mediated by ROS-JNK signaling pathways.Urolithiasis · 2019Article
- Calcium Carbonate Nanoparticles Can Activate the Epithelial⁻Mesenchymal Transition in an Experimental Gastric Cancer Model.Biomedicines · 2019Article
- Comprehensive organic profiling of biological particles derived from blood.Scientific reports · 2018Article
- Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1.Scientific reports · 2017Article
- Pleomorphic bacteria-like structures in human blood represent non-living membrane vesicles and protein particles.Scientific reports · 2017Article
- Formation and characteristics of biomimetic mineralo-organic particles in natural surface water.Scientific reports · 2016Article
- Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions.Scientific reports · 2016Article
- Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.EBioMedicine · 2016Article
- Matrix Gla-Protein (MGP) Not Only Inhibits Calcification in Large Arteries But Also May Be Renoprotective: Connecting the Dots.EBioMedicine · 2016Article
- Nanoparticle Tracking Analysis for the Enumeration and Characterization of Mineralo-Organic Nanoparticles in Feline Urine.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectopic calcification is associated with various human diseases, including atherosclerosis, cancer, chronic kidney disease, and diabetes mellitus. Although mineral nanoparticles have been detected in calcified blood vessels, the nature and role of these particles in the human body remain unclear. Here we show for the first time that human kidney tissues obtained from end-stage chronic kidney disease or renal cancer patients contain round, multilamellar mineral particles of 50 to 1,500 nm, whereas no particles are observed in healthy controls. The mineral particles are found mainly in the extracellular matrix surrounding the convoluted tubules, collecting ducts and loops of Henle as well as within the cytoplasm of tubule-delineating cells, and consist of polycrystalline calcium phosphate similar to the mineral found in bones and ectopic calcifications. The kidney mineral nanoparticles contain several serum proteins that inhibit ectopic calcification in body fluids, including albumin, fetuin-A, and apolipoprotein A1. Since the mineralo-organic nanoparticles are found not only within calcified deposits but also in areas devoid of microscopic calcifications, our observations indicate that the nanoparticles may represent precursors of calcification and renal stones in humans.
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