Evidence map›Paper›PMID 26497036›Full record

ArticleMolecular neurobiology2016

Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.

Matthieu T Castex, Arnaud Arabo, Magalie Bénard, Vincent Roy, Vadim Le Joncour, Gaëtan Prévost, Jean-Jacques Bonnet, Youssef Anouar, Anthony Falluel-Morel

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Matthieu T CastexInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France.
Arnaud AraboSciences Faculty, University of Rouen, 76821, Mont-Saint-Aignan, France.
Magalie BénardPRIMACEN, Institute for Research and Innovation in Biomedicine, University of Rouen, 76821, Mont-Saint-Aignan, France.
Vincent RoyPSY-NCA, EA4700, University of Rouen, 76821, Mont-Saint-Aignan, France.
Vadim Le JoncourInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France.
Gaëtan PrévostInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France.
Jean-Jacques BonnetInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France.
Youssef AnouarInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France. youssef.anouar@univ-rouen.fr.
Anthony Falluel-MorelInserm, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, Normandy University, Mont-Saint-Aignan, 76821, France.
Université de Rouen Normandie · FRInserm · FRInstitute for Research and Innovation in Biomedicine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenoprotein T (SelT) is a newly discovered thioredoxin-like protein, which is abundantly but transiently expressed in the neural lineage during brain ontogenesis. Because its physiological function in the brain remains unknown, we developed a conditional knockout mouse line (Nes-Cre/SelT

Indexed as

Behavior, AnimalAnimalsAnimals, NewbornApoptosisAstrocytesBrainCell ProliferationCell SurvivalHomeostasisHyperkinesisIntegrasesMice, Inbred C57BLMice, KnockoutNervous SystemNervous System MalformationsNestinCre recombinaseIntegrasesNestinReactive Oxygen SpeciesSelenoproteinsselenoprotein T, mouseAntioxidantBehavioral deficitBrain ontogenesisKnockout miceNeuroprotection

Identifiers

PMID26497036
OpenAlexW1835570408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.