SynthesisParasites & vectors2015
Modelling the distribution and transmission intensity of lymphatic filariasis in sub-Saharan Africa prior to scaling up interventions: integrated use of geostatistical and mathematical modelling.
Synthesis in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Standardisation of lymphatic filariasis microfilaraemia prevalence estimates based on different diagnostic methods: a systematic review and meta-analysis.Parasites & vectors · 2020Pooled it
- Assessment of transmission in areas of uncertain endemicity for lymphatic filariasis in Brazil.PLoS neglected tropical diseases · 2019Pooled it
- Antibodies to Tick Salivary Antigens AV422 and Calreticulin in Patients With Spotted Fever Group Rickettsioses and Other Febrile Illnesses in Northern Tanzania.The Journal of infectious diseases · 2026Article
- Evidence based targeting of districts for active surveillance of skin-related neglected tropical diseases in Ghana.PLOS global public health · 2026Article
- Bayesian hierarchical spatial ecological model assessing the nexus of vegetation index, insecticide-treated bed-nets and livestock cattle density on lymphatic filariasis transmission.BMC public health · 2025Article
- Using Model-Based Geostatistics to Refine Population-Based Estimates of Trachoma Prevalence: Update from a Technical Consultation.The American journal of tropical medicine and hygiene · 2025Article
- Integrating geospatial tools is crucial for enhancing control strategies against human lymphatic filarial infections in Ghana: A comprehensive review.Parasite epidemiology and control · 2025Review
- Examining the overlap in lymphatic filariasis prevalence and malaria insecticide-treated net access-use in endemic Africa.PLoS neglected tropical diseases · 2025Article
- Impact of Environmental Factors on the Distribution Patterns of Nephropathia Epidemica Cases in Western Europe.Environmental health perspectives · 2025Article
- Safety and effectiveness of triple-drug therapy with ivermectin, diethylcarbamazine, and albendazole in reducing lymphatic filariasis prevalence and clearing circulating filarial antigens in Mombasa, Kenya.Infectious diseases of poverty · 2025Article
- The role of molecular xenomonitoring for assessing the impact of Ivermectin, Diethylcarbamazine Citrate and Albendazole triple-drug treatment against lymphatic filariasis: A cross-sectional study in the Kenyan coastal region.PLOS global public health · 2025Article
- Risk Factors for Spotted Fever Group Rickettsioses in Kilimanjaro Region, Tanzania.Open forum infectious diseases · 2024Article
- Molecular xenomonitoring reveals Anopheles funestus and An. rivulorum as the primary vectors of lymphatic filariasis in coastal Kenya.Parasites & vectors · 2024Article
- Subnational Projections of Lymphatic Filariasis Elimination Targets in Ethiopia to Support National Level Policy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Modelling spatiotemporal patterns of visceral leishmaniasis incidence in two endemic states in India using environment, bioclimatic and demographic data, 2013-2022.PLoS neglected tropical diseases · 2024Article
- Observational
- Spatial predictive risk mapping of lymphatic filariasis residual hotspots in American Samoa using demographic and environmental factors.PLoS neglected tropical diseases · 2023Article
- Using model-based geostatistics for assessing the elimination of trachoma.PLoS neglected tropical diseases · 2023Article
- Use of medicinal plants as a remedy against lymphatic filariasis: Current status and future prospect.Health science reports · 2023Article
- A game-theoretic model of lymphatic filariasis prevention.PLoS neglected tropical diseases · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundLymphatic filariasis (LF) is one of the neglected tropical diseases targeted for global elimination. The ability to interrupt transmission is, partly, influenced by the underlying intensity of transmission and its geographical variation. This information can also help guide the design of targeted surveillance activities. The present study uses a combination of geostatistical and mathematical modelling to predict the prevalence and transmission intensity of LF prior to the implementation of large-scale control in sub-Saharan Africa.
methodsA systematic search of the literature was undertaken to identify surveys on the prevalence of Wuchereria bancrofti microfilaraemia (mf), based on blood smears, and on the prevalence of antigenaemia, based on the use of an immuno-chromatographic card test (ICT). Using a suite of environmental and demographic data, spatiotemporal multivariate models were fitted separately for mf prevalence and ICT-based prevalence within a Bayesian framework and used to make predictions for non-sampled areas. Maps of the dominant vector species of LF were also developed. The maps of predicted prevalence and vector distribution were linked to mathematical models of the transmission dynamics of LF to infer the intensity of transmission, quantified by the basic reproductive number (R0).
resultsThe literature search identified 1267 surveys that provide suitable data on the prevalence of mf and 2817 surveys that report the prevalence of antigenaemia. Distinct spatial predictions arose from the models for mf prevalence and ICT-based prevalence, with a wider geographical distribution when using ICT-based data. The vector distribution maps demonstrated the spatial variation of LF vector species. Mathematical modelling showed that the reproduction number (R0) estimates vary from 2.7 to 30, with large variations between and within regions.
conclusionsLF transmission is highly heterogeneous, and the developed maps can help guide intervention, monitoring and surveillance strategies as countries progress towards LF elimination.
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