ArticleScientific reports2015
Integrated analysis of miRNA and mRNA paired expression profiling of prenatal skeletal muscle development in three genotype pigs.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
- Review
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- Integrated analysis of expression profiles with meat quality traits in cattle.Scientific reports · 2022Article
- A Comparative Analysis of Metabolic Profiles of Embryonic Skeletal Muscle from Lantang and Landrace Pigs.Animals : an open access journal from MDPI · 2022Article
- A Novel miRNA Y-56 Targeting IGF-1R Mediates the Proliferation of Porcine Skeletal Muscle Satellite Cells Through AKT and ERK Pathways.Frontiers in veterinary science · 2022Article
- MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury.Bioengineered · 2021Article
- Role of MiR-325-3p in the Regulation of CFL2 and Myogenic Differentiation of C2C12 Myoblasts.Cells · 2021Article
- Dynamic transcriptome profiles of postnatal porcine skeletal muscle growth and development.BMC genomic data · 2021Article
- Skeletal Muscle Transcriptome Analysis of Hanzhong Ma Duck at Different Growth Stages Using RNA-Seq.Biomolecules · 2021Article
- Profiling and Functional Analysis of Long Noncoding RNAs and mRNAs during Porcine Skeletal Muscle Development.International journal of molecular sciences · 2021Article
- Role of microRNAs in myogenesis and their effects on meat quality in pig - A review.Asian-Australasian journal of animal sciences · 2020Article
- miR-206 knockout shows it is critical for myogenesis and directly regulates newly identified target mRNAs.RNA biology · 2020Article
- Analysis of miRNAs and their target genes associated with mucosal damage caused by transport stress in the mallard duck intestine.PloS one · 2020Article
- Biological Differentiation of Dampness-Heat Syndromes in Chronic Hepatitis B: From Comparative MicroRNA Microarray Profiling to Biomarker Identification.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Identification and Characterization of lncRNAs Related to the Muscle Growth and Development of Japanese Flounder (Frontiers in genetics · 2020Article
- Transcriptome analysis of miRNA and mRNA in the livers of pigs with highly diverged backfat thickness.Scientific reports · 2019Article
- Differentially expressed mRNAs, proteins and miRNAs associated to energy metabolism in skeletal muscle of beef cattle identified for low and high residual feed intake.BMC genomics · 2019Article
- Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs.Frontiers in genetics · 2019Article
- Comprehensive Analysis of MicroRNA⁻Messenger RNA from White Yak Testis Reveals the Differentially Expressed Molecules Involved in Development and Reproduction.International journal of molecular sciences · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) play a vital role in muscle development by binding to messenger RNAs (mRNAs). Based on prenatal skeletal muscle at 33, 65 and 90 days post-coitus (dpc) from Landrace, Tongcheng and Wuzhishan pigs, we carried out integrated analysis of miRNA and mRNA expression profiling. We identified 33, 18 and 67 differentially expressed miRNAs and 290, 91 and 502 mRNA targets in Landrace, Tongcheng and Wuzhishan pigs, respectively. Subsequently, 12 mRNAs and 3 miRNAs differentially expressed were validated using quantitative real-time PCR (qPCR), and 5 predicted miRNA targets were confirmed via dual luciferase reporter or western blot assays. We identified a set of miRNAs and mRNA genes differentially expressed in muscle development. Gene ontology (GO) enrichment analysis suggests that the miRNA targets are primarily involved in muscle contraction, muscle development and negative regulation of cell proliferation. Our data indicated that more mRNAs are regulated by miRNAs at earlier stages than at later stages of muscle development. Landrace and Tongcheng pigs also had longer phases of myoblast proliferation than Wuzhishan pigs. This study will be helpful to further explore miRNA-mRNA interactions in myogenesis and aid to uncover the molecular mechanisms of muscle development and phenotype variance in pigs.
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